Targeted drug delivery in cervical carcinoma: the role of gold nanoparticles in enhancing treatment efficacy.

IF 3.5 4区 医学 Q2 ONCOLOGY
Sampada D Dalvi, Mukesh P Ratnaparkhi, Rohan N Badhe, Bhakti S Matkar, Kapil A Kaninde
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引用次数: 0

Abstract

As the fourth most common cancer affecting women globally, cervical cancer presents a significant health challenge. Nanotechnology offers a promising new frontier for treatment, with gold nanoparticles (AuNPs) emerging as a powerful tool for enhancing therapeutic effectiveness.This review focuses on the synthesis of AuNPs and their strategic application in targeted drug delivery systems to combat cervical cancer. Gold nanoparticles are exceptionally well suited for this role due to a unique combination of properties, including their small size, high surface-area-to-volume ratio, excellent stability, and biocompatibility. These traits make them ideal vehicles for medical use.Beyond targeted drug delivery, AuNPs can also act as radiosensitizers, increasing the susceptibility of cancer cells to radiation. This synergy has the potential to make radiation therapy more precise and effective, highlighting the multifaceted role of gold nanoparticles in developing more advanced and targeted treatments for cervical cancer.

靶向给药宫颈癌:金纳米颗粒在提高治疗疗效中的作用。
宫颈癌是全球影响妇女的第四大常见癌症,对健康构成重大挑战。纳米技术为治疗提供了一个有前景的新领域,金纳米颗粒(AuNPs)正在成为提高治疗效果的有力工具。本文就AuNPs的合成及其在靶向给药系统中的应用进行综述。金纳米颗粒由于其独特的特性组合,包括小尺寸、高表面积体积比、优异的稳定性和生物相容性,非常适合这一角色。这些特性使它们成为理想的医疗工具。除了靶向药物递送,aunp还可以作为放射增敏剂,增加癌细胞对辐射的易感性。这种协同作用有可能使放射治疗更加精确和有效,突出了金纳米颗粒在开发更先进和更有针对性的宫颈癌治疗方面的多方面作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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