The association between injectable non-steroidal anti-inflammatory drugs and acute kidney injury in dogs and cats.

IF 1.9 2区 农林科学 Q2 VETERINARY SCIENCES
Matthew K Wun, Michael H Court, Nicolas F Villarino, Richard Malik
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引用次数: 0

Abstract

Over the past 20 years, injectable non-steroidal anti-inflammatory drugs (NSAIDs) have become widely adopted to provide routine analgesia to dogs and cats, including perioperatively. This is despite growing evidence associating their use with acute kidney injury, particularly in relation to the use of meloxicam in cats. In this Perspective, we summarise the evidence obtained from pharmacovigilance agencies and the veterinary literature, examine why proponents of injectable NSAIDs appear to discard this evidence, and discuss whether injectable NSAIDs are an obligatory component of multimodal analgesia. Finally, we offer alternative analgesic drug regimens and call for further research that could be undertaken before injectable NSAIDs can be used safely in dogs and cats.

可注射非甾体抗炎药与狗和猫急性肾损伤之间的关系。
在过去的20年里,可注射的非甾体抗炎药(NSAIDs)已被广泛用于犬和猫的常规镇痛,包括围手术期。尽管越来越多的证据表明它们的使用与急性肾损伤有关,特别是与猫使用美洛昔康有关。在这一观点中,我们总结了从药物警戒机构和兽医文献中获得的证据,研究了为什么注射类非甾体抗炎药的支持者似乎放弃了这一证据,并讨论了注射类非甾体抗炎药是否是多模式镇痛的强制性组成部分。最后,我们提供了替代的镇痛药物方案,并呼吁在可注射的非甾体抗炎药可以安全地用于狗和猫之前进行进一步的研究。
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来源期刊
Veterinary anaesthesia and analgesia
Veterinary anaesthesia and analgesia 农林科学-兽医学
CiteScore
3.10
自引率
17.60%
发文量
91
审稿时长
97 days
期刊介绍: Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.
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