Major contributors to musculoskeletal pain among children receiving hemodialysis.

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-10-16 DOI:10.1007/s00467-025-06964-2

Doaa Mosad Mosa, Mohamed Taman, Abobakr Abdelgalil, Doaa Shokry Alemam, Mohamed M Zedan, Mai S Korkor

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引用次数: 0

Abstract

Background: Children who are undergoing hemodialysis are vulnerable to musculoskeletal (MSK) abnormalities. These conditions can potentially lead to functional impairments and diminished health-related quality of life. Hence, this study was to explore the prevalence of MSK pain in children receiving hemodialysis and the factors associated with this MSK pain.

Methods: This cross-sectional study was conducted on a group of children undergoing hemodialysis at the nephrology unit, Mansoura University Children's Hospital, from December 2022 to January 2024. Patient demographics, clinical data, musculoskeletal findings, physical function, quality of life assessment parameters, laboratory data, and Dual Energy X-ray Absorptiometry (DEXA) results were collected. All patients were classified into two groups: patients with MSK pain and those without any MSK pain.

Results: The total number of cases with MSK pain was 32 (64%). The most frequent musculoskeletal manifestations were: osteoporosis/osteopenia (64%), myalgia (64%), cramps (60%), arthralgia/arthritis (32%), and regional pain (32%). MSK pain was independently associated with longer dialysis duration, the presence of comorbidity, childhood health assessment questionnaire results, pediatric quality of life inventory, hemoglobin level, serum uric acid, calcium × phosphate product, and DEXA (Z-score).

Conclusions: Involvement of the MSK system is a common morbidity in children with hemodialysis. Calcium × phosphate product (p = 0.026) and vitamin D level (p = 0.003) were the most significant factors associated with MSK pain in multivariate regression analysis.

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接受血液透析的儿童肌肉骨骼疼痛的主要原因。

背景：接受血液透析的儿童容易发生肌肉骨骼（MSK）异常。这些情况可能导致功能障碍和健康相关生活质量下降。因此，本研究旨在探讨接受血液透析的儿童MSK疼痛的患病率以及与这种MSK疼痛相关的因素。方法：本横断面研究于2022年12月至2024年1月在曼苏拉大学儿童医院肾病科进行血液透析的一组儿童。收集患者人口统计学、临床资料、肌肉骨骼发现、身体功能、生活质量评估参数、实验室数据和双能x线吸收仪（DEXA）结果。所有患者分为两组：MSK疼痛组和无MSK疼痛组。结果：MSK疼痛32例（64%）。最常见的肌肉骨骼表现为：骨质疏松/骨质减少（64%）、肌痛（64%）、痉挛（60%）、关节痛/关节炎（32%）和局部疼痛（32%）。MSK疼痛与较长的透析时间、合并症的存在、儿童健康评估问卷结果、儿童生活质量量表、血红蛋白水平、血清尿酸、x磷酸钙产物和DEXA （Z-score）独立相关。结论：MSK系统受累是儿童血液透析的常见疾病。多因素回归分析显示，钙×磷酸盐产品（p = 0.026）和维生素D水平（p = 0.003）是与MSK疼痛相关的最显著因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.