First Case Report Of Letendraea helminthicola Endophthalmitis After Penetrating Ocular Trauma from a Cat Scratch.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-10-16 DOI:10.1080/09273948.2025.2569721

Natpachara Emmaneerat, Lita Uthaithammarat, Vannarut Satitpitakul, Wijak Kongwattananon

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引用次数: 0

Abstract

Purpose: To report the first documented case of endophthalmitis caused by Letendraea helminthicola following a penetrating globe injury from a cat scratch.

Methods: A 32-year-old male presented with post-traumatic endophthalmitis after a penetrating ocular injury caused by a cat scratch. Clinical evaluation, serial ophthalmic imaging, microbiological investigations, and polymerase chain reaction (PCR) analysis of conjunctival tissue were performed.

Results: Despite initial improvement with empiric broad-spectrum antibiotics, the patient developed progressive vitritis requiring multiple pars plana vitrectomies. Conventional microbiological cultures remained negative; however, PCR identified L. helminthicola from conjunctival tissue. Targeted antifungal therapy with systemic and intravitreal voriconazole led to infection control, although visual recovery was limited due to macular involvement.

Conclusion: L. helminthicola can cause post-traumatic fungal endophthalmitis following ocular injuries involving animal scratches. Molecular diagnostics are critical for identifying rare pathogens, and prompt targeted antifungal therapy is essential for optimizing outcomes.

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猫抓伤致穿透性眼外伤后眼内炎1例。

目的：报告第一例有文献记载的眼内炎病例，该病例是由猫抓伤造成的穿透性眼球损伤引起的。方法：一个32岁的男性提出创伤后眼内炎后穿透性眼损伤引起的猫抓伤。临床评估，一系列眼科成像，微生物调查和结膜组织聚合酶链反应（PCR）分析。结果：尽管最初使用经验性广谱抗生素有所改善，但患者发展为进行性玻璃体炎，需要进行多次玻璃体切割手术。常规微生物培养呈阴性；然而，PCR鉴定出helminthicola来自结膜组织。全身和玻璃体内伏立康唑靶向抗真菌治疗可控制感染，但由于黄斑受累，视力恢复有限。结论：动物抓伤后眼内真菌可引起眼内真菌炎。分子诊断对于识别罕见病原体至关重要，而及时的靶向抗真菌治疗对于优化结果至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.