The relationship between cognitive domains and everyday functioning in Alzheimer's disease.

IF 2.9 3区心理学 Q3 NEUROSCIENCES

Neuropsychology Pub Date : 2026-02-01 Epub Date: 2025-10-16 DOI:10.1037/neu0001038

Sophie M van der Landen, Hanneke F M Rhodius-Meester, Merel C Postema, Roos J Jutten, Mukrabe E Tewolde, Camar V Bohnen, Argonde C van Harten, Charlotte E Teunissen, Rudolf W H Ponds, Benjamin D Schalet, Wiesje M van der Flier, Sietske A M Sikkes

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引用次数: 0

Abstract

Objective: Alzheimer's disease (AD) causes increasing cognitive and functional impairments, yet if and how cognition impacts functioning remains unclear. Here, we assessed the relationship between cognitive domains and everyday functioning in participants with AD.

Method: In this cross-sectional study, we included participants with biomarker-confirmed AD with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or dementia from the Amsterdam Dementia Cohort. Cognition was assessed with a standardized neuropsychological test battery divided into domains using exploratory factor analysis (EFA). These were used as input for structural equation modeling (SEM) to calculate the unique associations with everyday functioning, measured with the well-validated study partner-based Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q). Model fit of the SEM and its associations were described in standardized paths (std.lv).

Results: A total of 613 participants were included, mean age ± SD = 65 ± 8 years, 310(51%) female, with a mean A-IADL-Q of 50.2 ± 9.3. The majority had a diagnosis of dementia (n = 443, 72%), followed by MCI (n = 100, 16%) and SCD (n = 70, 11%). SEM analysis, χ²(137, N = 613) = 1072.17, p < .001, showed that, of the four cognitive domains identified using EFA, "memory" (std.lv = 0.33) and "visual attention, mental flexibility, and visuoconstruction" (std.lv = 0.29) were related to A-IADL-Q, while "working memory, shifting, fluency, and inhibition" and "naming" were not.

Conclusions: Lower performance in memory and visual attention, mental flexibility, and visuoconstruction was related to more difficulties in everyday functioning. A better understanding of how cognition relates to everyday functioning has important implications for personalized care strategies and trial outcomes. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

查看原文本刊更多论文

阿尔茨海默病中认知域与日常功能的关系。

目的：阿尔茨海默病（AD）导致越来越多的认知和功能障碍，但认知是否以及如何影响功能尚不清楚。在这里，我们评估了AD患者的认知领域和日常功能之间的关系。方法：在这项横断面研究中，我们纳入了来自阿姆斯特丹痴呆队列的生物标志物证实的AD伴有主观认知能力下降（SCD）、轻度认知障碍（MCI）或痴呆的参与者。认知评估采用标准化的神经心理测试电池，使用探索性因素分析（EFA）划分域。这些数据被用作结构方程建模（SEM）的输入，以计算与日常功能的独特关联，并通过基于研究伙伴的阿姆斯特丹日常生活工具活动问卷（A-IADL-Q）进行测量。扫描电镜的模型拟合及其关联用标准化路径描述（std.lv）。结果：共纳入613例受试者，平均年龄±SD = 65±8岁，女性310例（51%），平均A- iadl - q为50.2±9.3。大多数被诊断为痴呆（n = 443, 72%），其次是MCI （n = 100, 16%）和SCD （n = 70, 11%）。SEM分析，χ 2 (137, N = 613) = 1072.17, p < .001，结果表明，在EFA识别的4个认知领域中，“记忆”（std.lv = 0.33）和“视觉注意、心理灵活性和视觉构建”（std.lv = 0.29）与A-IADL-Q相关，“工作记忆、移动、流畅性和抑制”和“命名”与A-IADL-Q无关。结论：记忆和视觉注意力、心理灵活性和视觉构建方面的较低表现与日常功能的更多困难有关。更好地了解认知与日常功能的关系对个性化护理策略和试验结果具有重要意义。（PsycInfo Database Record (c) 2025 APA，版权所有）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology 医学-神经科学

CiteScore

4.10

自引率

4.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.