Extracranial Internal Carotid Artery Doppler Ultrasound Imaging Findings in Kuwaiti Children With Sickle Cell Disease and Without Neurological Symptoms.

IF 1.4 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-10-16 DOI:10.1002/jcu.70093

Adekunle Adekile, Saad A Asbeutah, Akram M Asbeutah

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引用次数: 0

Abstract

Purpose: The time-averaged mean of the maximum velocity (TAMMV) in both intracranialinternal carotid artery (iICA) and extracranial (eICA) and hematological variables in sickle cell disease (SCD) patients was investigated.

Methods: Transcranial Doppler Imaging (TCDI) was performed with a 1-3 MHz phased-array and Linear 3.3-10 MHz transducers for both ICA. Patients were divided into three groups according to age and genotype. Blood parameters were determined using routine methods. ANOVA and linear regression analyses were done.

Results: There were 59 patients, 24 males and 35 females (26 with HbSS, 29 HbSβ⁰, and 4 with HbSD). The average age ± SD for all patients was 10.8 ± 3.2 years. The average ± SD TAMMV for iICA was 72.4 ± 11.3 and for eICA was 63.4 ± 25.8 cm/s. There were no significant differences among patients with different genotypes. The iICA and eICA TMMAV according to age (average ± SD) for all were 72.4 ± 11.3 for iICA and 63.4 ± 25.8 for eICA. Age, platelet count, neutrophil count, LDH, and bilirubin showed no significant correlation with TAMMV in the iICA; however, it was significant in the eICA (p < 0.05).

Conclusion: A significant correlation was found between age and markers of SCD severity and TAMMV in the eICA, but not with iICA. Therefore, the former might be a more important indicator of vasculopathy in our patients.

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科威特镰状细胞病儿童无神经症状的颅外颈内动脉多普勒超声显像

目的：探讨镰状细胞病（SCD）患者颅内颈内动脉（iICA）和颅外动脉（eICA）最大流速（tammm）的时间平均平均值和血液学指标。方法：采用1-3 MHz相控阵和3.3-10 MHz线性换能器进行经颅多普勒成像（TCDI）。患者按年龄和基因型分为三组。采用常规方法测定血液参数。方差分析和线性回归分析。结果：59例患者，男24例，女35例（HbSS 26例，HbSS β0 29例，HbSD 4例）。所有患者的平均年龄±SD为10.8±3.2岁。iICA的平均±SD TAMMV为72.4±11.3 cm/s， eICA的平均±SD TAMMV为63.4±25.8 cm/s。不同基因型患者间无显著差异。iICA和eICA的TMMAV按年龄（平均±SD）分别为72.4±11.3和63.4±25.8。年龄、血小板计数、中性粒细胞计数、LDH、胆红素与iICA患者tammm无显著相关性；结论：年龄与SCD严重程度和TAMMV标志物在eICA中存在显著相关性，但与iICA无关。因此，前者可能是我们患者血管病变的一个更重要的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.