A pyridine-promoted umpolung strategy for the α-amination of styrenes via pyridinium salt intermediates.

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-10-17 DOI:10.1039/d5ob01405k

Weibin Fan, Shahid Ali, Xiaozhong Wang, Liyan Dai, Jianhai Yang, Jia Guo

引用次数: 0

Abstract

Pyridine acts as a novel catalyst, promoting the umpolung α-amination of styrenes. Umpolung of α-C in styrenes is achieved by the formation of (α-phenylvinyl)pyridinium, and depyridination will give the α-amination products. 23 α-amination products are synthesized by this strategy. The reaction mechanism is analysed by DFT theoretical calculations.

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吡啶促进苯乙烯经吡啶盐中间体α-胺化的掺杂策略。

吡啶作为一种新型催化剂，促进苯乙烯的非均匀α-胺化反应。苯乙烯中的α-C通过生成（α-苯基乙烯基）吡啶而被分解，脱吡啶生成α-胺化产物。用该方法合成了23个α-胺化产物。通过DFT理论计算分析了反应机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.