Endogenous Electric Fields: A Natural Driver for Infrared-Activated Transparent Electronic Skin in Wound Healing

IF 9.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-10-17 DOI:10.1021/acs.nanolett.5c04223

Futing Wang, Suping Deng, Linxuan Liu, Ningbo Zhang, Changxiao Song, Yutang Zhou, Xiaofei Fu, Yuting Jiang, Man Liu, Yueqiang Hu, Hongfen Yang, Dan Yang, Wenbin Zhong, Zhuo Chen, Ren Cai, Weihong Tan

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Abstract

A flexible, self-powered, and transparent electronic skin (e-skin) is constructed by combining endogenous electric field modulation and infrared thermal stimulation to accelerate wound healing. The e-skin comprises (1) a transparent conductive layer for real-time wound monitoring, fabricated by thermal deposition of hexadecyltrimethylammonium bromide (CTAB)-functionalized carbon nanotubes (C-MWCNTs) with polydimethylsiloxane (PDMS); (2) a photothermal interface using Pd@Au nanoframes for infrared therapy; and (3) self-powered electric fields mimicking bioelectric signals. Antibacterial assays of the e-skin showed >160% bacterial suppression at the peak output of 0.25–0.59 V and 90–140% suppression at the baseline output of 0.05–0.12 V. In vitro tests demonstrated 90% E. coli elimination within 10 min. In vivo studies on rabbits revealed a 50% reduction in healing time (7 days) via synergistic photothermal-electrical therapy. This e-skin offers a promising approach to advanced wound care.

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内源性电场：红外激活透明电子皮肤在伤口愈合中的自然驱动力

利用内源性电场调制与红外热刺激相结合，构建了一种灵活、自供电、透明的电子皮肤（e-skin），以加速伤口愈合。电子皮肤包括：(1)透明导电层，用于实时伤口监测，由十六烷基三甲基溴化铵（CTAB）功能化碳纳米管（C-MWCNTs）和聚二甲基硅氧烷（PDMS）热沉积制成；(2)利用Pd@Au纳米框架进行红外治疗的光热界面；(3)模拟生物电信号的自供电电场。在0.25 ~ 0.59 V的峰值电压下，电子皮的抑菌效果为160%；在0.05 ~ 0.12 V的基线电压下，抑菌效果为90 ~ 140%。体外试验表明，10分钟内可消除90%的大肠杆菌。兔体内研究显示，通过协同光热-电疗法，愈合时间缩短50%（7天）。这种电子皮肤为高级伤口护理提供了一种很有前途的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.