Palladium-Catalyzed Carbonylative Cross-Coupling of Aryl (Pseudo)halides and Cyclopropanols.

Abstract

An efficient and general method for the synthesis of 1,4-diketones has been achieved through the palladium-catalyzed carbonylative cross-coupling of aryl halides with cyclopropanols. This methodology shows excellent compatibility with various functional groups and expands the scope for the synthesis of symmetrical and unsymmetrical 1,4-diketones with good efficiency. The synthetic utility of the diketones was demonstrated, and a plausible mechanism was also discussed.