Breast cancer immunophenotypes are associated with exposure to mixtures of organochlorine pesticides and trace elements among Northern Mexican women

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-10-08 DOI:10.1016/j.jtemb.2025.127777

Ángel Mérida-Ortega , Rodrigo Ugalde-Resano , Mariano E. Cebrián , Lizbeth López-Carrillo

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引用次数: 0

Abstract

Purpose

To evaluate the association between breast cancer (BC) immunophenotypes and mixtures of trace elements and organochlorine pesticides (OCP), as well as to identify their main contributors within the mixtures and their potential interactions.

Methods

We performed a secondary analysis including 386 population-based controls and 336 incident BC cases. Based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status, we defined three BC immunophenotypes: HR+ /HER2 −, HER2 + and triple negative (HR−/HER2 −). We evaluated 24 serum OCP and 10 urinary MM.

Results

Through weighted quantile sum (WQS) regressions, we observed that mixtures containing hexachlorocyclohexane (α and β), and tin, were positively related to HR+ /HER2 − (OR = 6.03; 95 %CI 2.74,13.28), HER2 + (OR = 2.95; 95 %CI 0.43,19.97) and triple negative cases (OR = 3.56; 95 % CI 1.26,10.01). In contrast, we found that mixtures mainly constituted by p’p DDE, cis-nonachlor and molybdenum were negatively related to all BC immunophenotypes: HR+ /HER2 − (OR = 0.09; 95 %CI 0.05,0.18); HER2 + (OR = 0.14; 95 %CI 0.02,0.85) and triple negative (OR = 0.19; 95 %CI 0.05,0.70). We observed that almost all OCP, but none trace elements, interacted synergistically and significantly with each other on BC association.

Conclusion

This study is among the first to demonstrate the complexity of combined exposures to organic and inorganic environmental contaminants and their associations with distinct BC immunophenotypes.

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在墨西哥北部妇女中，乳腺癌免疫表型与接触有机氯农药和微量元素的混合物有关。

目的：评价乳腺癌（BC）免疫表型与微量元素和有机氯农药（OCP）混合物之间的关系，并确定其在混合物中的主要贡献者及其潜在的相互作用。方法：我们进行了二次分析，包括386例基于人群的对照和336例突发BC病例。基于激素受体（HR）和人表皮生长因子受体2 （HER2）状态，我们定义了三种BC免疫表型：HR+ /HER2 -，HER2 + 和三阴性（HR-/HER2 -）。结果：通过加权分位数和（WQS）回归，我们观察到含有六氯环己烷（α和β）和锡的混合物与HR+ /HER2 - （OR = 6.03; 95 %CI 2.74,13.28）、HER2 + （OR = 2.95; 95 %CI 0.43,19.97）和三阴性病例（OR = 3.56; 95 %CI 1.26,10.01）呈正相关。相反，我们发现主要由p'p DDE、顺式非氯胺和钼组成的混合物与所有BC免疫表型呈负相关：HR+ /HER2 - (OR = 0.09; 95 %CI 0.05,0.18)；HER2 + （OR = 0.14; 95 %CI 0.02,0.85）和三阴性（OR = 0.19; 95 %CI 0.05,0.70）。我们观察到几乎所有的OCP，但没有微量元素，在BC关联中相互协同作用显著。结论：本研究首次证明了有机和无机环境污染物联合暴露的复杂性及其与不同BC免疫表型的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.