Tapeworm infection incidence in rural Japan points to a common environmental source of infection.

Drug discoveries & therapeutics Pub Date : 2025-11-15 Epub Date: 2025-10-16 DOI:10.5582/ddt.2025.01070

Dhammika Leshan Wannigama, Mohan Amarasiri, Phatthranit Phattharapornjaroen, Cameron Hurst, Yu Suzuki, Daisuke Akaneya, Mika Moriya, Taichi Adachi, Yoshikazu Okuma, Daisuke Ishizawa, Hitoshi Ishikawa, Kazuhiko Miyanaga, Longzhu Cui, Kazunori Moriya, Hirotake Mori, Naveen Kumar Devanga Ragupathi, Yoshitaka Shimotai, Daisuke Sano, Takashi Furukawa, Kazunari Sei, Talerngsak Kanjanabuch, Paul G Higgins, Tetsuji Aoyagi, Anthony Kicic, Sam Trowsdale, Parichart Hongsing, Aisha Khatib, Kenji Shibuya, Shuichi Abe, Hiroshi Hamamoto

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Abstract

Dibothriocephalus nihonkaiensis is a zoonotic tapeworm transmitted to humans through consumption of raw or undercooked fish or wild meat. Between 2022 and 2023, Yamagata Prefecture reported an increase in cases compared with 2017-2021, when none were observed. We conducted a clinical and environmental investigation to clarify infection sources. Four confirmed and one suspected patient were identified, all presenting with gastrointestinal symptoms. Exposures were linked to raw cherry salmon (Oncorhynchus masou) in three cases and undercooked bear meat in one case. Praziquantel treatment (10-20 mg/kg) was effective, with eight worms (76-210 cm) recovered. Environmental surveillance detected D. nihonkaiensis in 33.3% of bear feces (20/60) and 21.8% of wild fish samples (17/78). Phylogenetic analysis showed close genetic relatedness among human, bear, and fish isolates, indicating a shared transmission cycle. These findings confirm zoonotic transmission of D. nihonkaiensis in Yamagata and highlight the need for food safety awareness and environmental monitoring.

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绦虫感染在日本农村的发病率表明了一种常见的环境感染源。

nihonkaidibothricephalus nihonkaidibothricephalus是一种人畜共患绦虫，通过食用生的或未煮熟的鱼或野生肉类传播给人类。2022年至2023年期间，山形县报告的病例数与2017-2021年相比有所增加，而2017-2021年没有观察到病例。我们进行了临床和环境调查以澄清感染源。发现4名确诊患者和1名疑似患者，均出现胃肠道症状。其中三例与生樱桃鲑鱼（Oncorhynchus masou）有关，一例与未煮熟的熊肉有关。吡喹酮（10 ~ 20 mg/kg）处理有效，可回收8只虫（76 ~ 210 cm）。环境监测中熊粪中检出日本海夜蛾33.3%(20/60)，野生鱼类标本中检出21.8%（17/78）。系统发育分析显示，人类、熊和鱼类分离株之间的遗传亲缘关系密切，表明有一个共同的传播周期。这些结果证实了山形县日本海螺的人畜共患传播，强调了加强食品安全意识和环境监测的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drug discoveries & therapeutics

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