{"title":"Exploring erythropoiesis: aging through the lens of malaria and microgravity.","authors":"Paul Foucambert, Jing Wen Hang, Benoit Malleret","doi":"10.1016/j.pt.2025.09.008","DOIUrl":null,"url":null,"abstract":"<p><p>Erythropoiesis, the production of red blood cells (RBCs), is a tightly regulated process essential for hematologic health. This system significantly shifts during aging, impacting RBC production and function. In this review, we examine erythropoiesis stages and highlight major age-related changes in stem cells, transcription factors, and key regulators such as erythropoietin and iron. We then explore mechanisms driving the high prevalence of anemia in the elderly - chronic disease, sepsis, and unexplained anemia - while discussing current therapies and gaps in management. Finally, we introduce two underexplored models for studying aging RBCs: malaria and microgravity. Plasmodium infection and spaceflight mirror key features of age-related erythropoietic dysfunction and RBC morphological alterations, offering insights into mechanisms of anemia in the elderly.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":6.6000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.pt.2025.09.008","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Erythropoiesis, the production of red blood cells (RBCs), is a tightly regulated process essential for hematologic health. This system significantly shifts during aging, impacting RBC production and function. In this review, we examine erythropoiesis stages and highlight major age-related changes in stem cells, transcription factors, and key regulators such as erythropoietin and iron. We then explore mechanisms driving the high prevalence of anemia in the elderly - chronic disease, sepsis, and unexplained anemia - while discussing current therapies and gaps in management. Finally, we introduce two underexplored models for studying aging RBCs: malaria and microgravity. Plasmodium infection and spaceflight mirror key features of age-related erythropoietic dysfunction and RBC morphological alterations, offering insights into mechanisms of anemia in the elderly.
期刊介绍：
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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