{"title":"Role of N,N,N Trimethyl-L-alanyl-L-proline Betaine Levels in the Process of Myocardial Infarction.","authors":"Ziyang Wu, Dong Wang, Chengchun Tang","doi":"10.1007/s12265-025-10711-1","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of this study was to evaluate the relationship between N,N,N trimethyl-L-alanyl-L-proline betaine (TMAP) levels and myocardial infarction (MI). Causal relationship was estimated based on TMAP levels and MI data from genome-wide association studies (GWAS). The main analysis method of bidirectional two-sample Mendelian randomization (TSMR) was inverse variance weighting (IVW), with four other supplementary methods used. The IVW method yielded results indicating a negative correlation between TMAP levels and MI (IVW, odds ratio [OR] = 0.976, 95% confidence interval [CI]: 0.960-0.992, P = 0.004). In contrast, the inverse analysis did not provide evidence that MI affects TMAP levels (P > 0.05). This study provided evidence for the causal effect of TMAP levels on MI. It was not the case in the opposite situation. It is plausible that TMAP may serve as a protective factor in MI.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Translational Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12265-025-10711-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of this study was to evaluate the relationship between N,N,N trimethyl-L-alanyl-L-proline betaine (TMAP) levels and myocardial infarction (MI). Causal relationship was estimated based on TMAP levels and MI data from genome-wide association studies (GWAS). The main analysis method of bidirectional two-sample Mendelian randomization (TSMR) was inverse variance weighting (IVW), with four other supplementary methods used. The IVW method yielded results indicating a negative correlation between TMAP levels and MI (IVW, odds ratio [OR] = 0.976, 95% confidence interval [CI]: 0.960-0.992, P = 0.004). In contrast, the inverse analysis did not provide evidence that MI affects TMAP levels (P > 0.05). This study provided evidence for the causal effect of TMAP levels on MI. It was not the case in the opposite situation. It is plausible that TMAP may serve as a protective factor in MI.
期刊介绍：
Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research.
JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials.
JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.
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