Brain-Bone Axis in Physiological and Pathological Conditions.

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI:10.3390/ijms26199822

Luca Massaccesi, Massimiliano Marco Corsi Romanelli, Emanuela Galliera

引用次数: 0

Abstract

The brain-bone axis has garnered increasing attention over the years, leading to numerous studies that have unraveled the intricate bidirectional communication between the central nervous system (CNS) and skeletal metabolism. This review explores this profound relationship, examining the complex mechanisms that regulate it, the key players involved, and the clinical implications of its dysfunction in various pathological situations affecting the CNS and skeletal system. Ultimately, it emphasizes the potential of ongoing research to develop diagnostic tools, therapeutic interventions, and preventive strategies aimed at enhancing skeletal and neurological health.

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生理和病理条件下的脑-骨轴。

多年来，脑骨轴引起了越来越多的关注，导致许多研究揭示了中枢神经系统（CNS）和骨骼代谢之间复杂的双向交流。这篇综述探讨了这种深刻的关系，研究了调节它的复杂机制，所涉及的关键参与者，以及它在影响中枢神经系统和骨骼系统的各种病理情况下功能障碍的临床意义。最后，它强调了正在进行的研究在开发诊断工具、治疗干预和预防策略方面的潜力，这些研究旨在增强骨骼和神经系统的健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Molecular Sciences 化学-化学综合

自引率

10.70%

发文量

13472

审稿时长

1.7 months

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).