Electrochemical biosensing of Helicobacter pylori in gastrointestinal disease

IF 2.9 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-10-13 DOI:10.1016/j.cca.2025.120660

Ghada Al-Assi , Waleed K. Abdulsahib , Sanan Thaer Abdal-Wahab , G. Padma Priya , Subhashree Ray , J. Bethanney Janney , Vipasha Sharma , Ashish Singh Chauhan , Zafar Aminov

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引用次数: 0

Abstract

Helicobacter pylori (H. pylori) infection remains a major global health concern and is closely linked to peptic ulcers, gastritis, and gastric cancer. Rapid, accurate, and noninvasive diagnostic tools are essential for early detection and effective management. This review explores the emerging role of electrochemical biosensors in the detection of H. pylori, highlighting their potential to revolutionize gastrointestinal diagnostics. By integrating biorecognition elements with advanced transduction mechanisms, electrochemical biosensors offer high sensitivity, specificity, and portability. We examine recent advances in sensor design, including nanomaterial-enhanced platforms and multiplexed detection strategies, and discuss their clinical applicability. Bridging the gap between laboratory innovation and clinical implementation, this work underscores the promise of electrochemical biosensing as a transformative approach from bench to bedside in the diagnosis of H. pylori-related diseases.

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胃肠道疾病幽门螺杆菌的电化学生物传感。

幽门螺杆菌（h.p ylori）感染仍然是全球主要的健康问题，与消化性溃疡、胃炎和胃癌密切相关。快速、准确和无创的诊断工具对于早期发现和有效管理至关重要。这篇综述探讨了电化学生物传感器在幽门螺杆菌检测中的新兴作用，强调了它们在胃肠道诊断中的革命性潜力。通过将生物识别元件与先进的转导机制相结合，电化学生物传感器具有高灵敏度、特异性和便携性。我们研究了传感器设计的最新进展，包括纳米材料增强平台和多路检测策略，并讨论了它们的临床适用性。弥合实验室创新和临床实施之间的差距，这项工作强调了电化学生物传感作为一种从实验室到床边诊断幽门螺杆菌相关疾病的变革方法的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.