Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors.

IF 6.9 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-10-14 DOI:10.1016/j.celrep.2025.116437

Michael C Tackenberg, Kristina M Heliodoro, Lily C Melink, Yifan Liu, Kun Zhu, Mitchell A Lazar

引用次数: 0

Abstract

REV-ERB nuclear receptors are integrated into the molecular circadian clock present in most mammalian cells. Loss of REV-ERBs (REV-ERB DKO) within the suprachiasmatic nucleus (SCN) in vivo leads to a marked shortening of the circadian period, but it remains unclear whether REV-ERB regulation of circadian period is tissue autonomous, if it is conserved across tissues, and how it is established. Here, we show that period shortening in the absence of REV-ERBs is tissue autonomous, is consistent between brain and liver, and is brought about through derepression of clock transcription factors NPAS2 and CLOCK. Thus, in addition to disruption of synchrony with the external environment, our results demonstrate that the circadian impacts of REV-ERB loss also include the alteration of core circadian properties with tissue-specific consequences.

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正常的昼夜周期长度需要REV-ERB核受体抑制Npas2。

REV-ERB核受体被整合到大多数哺乳动物细胞的分子昼夜节律钟中。体内视交叉上核（SCN）内REV-ERB （REV-ERB DKO）的缺失导致昼夜节律周期明显缩短，但目前尚不清楚REV-ERB对昼夜节律周期的调节是否是组织自主的，它是否在组织中保守，以及它是如何建立的。在这里，我们发现在没有REV-ERBs的情况下，周期缩短是组织自主的，在大脑和肝脏之间是一致的，并且是通过降低时钟转录因子NPAS2和clock来实现的。因此，除了破坏与外部环境的同步外，我们的研究结果表明，REV-ERB丢失的昼夜节律影响还包括具有组织特异性后果的核心昼夜节律特性的改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.