TRPM2: a pivotal player in tumor progression and a promising therapeutic target.

IF 6 2区医学 Q1 ONCOLOGY

Cancer Cell International Pub Date : 2025-10-15 DOI:10.1186/s12935-025-03974-w

Zhigang Chen, Zhengheng Wu, Tianhan Xu, Fuqian Yu, Dongmei Wang

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Abstract

TRPM2, a member of the TRPM family, is a ubiquitously expressed non-selective cation channel located on cellular membranes. Activated by ADP-ribose (ADPR), this channel is prevalent across various normal tissues and plays a critical role in numerous physiological and pharmacological processes, particularly in maintaining calcium homeostasis. A substantial body of evidence indicates that elevated expression of TRPM2 is associated with various cancer types. Increased TRPM2 expression has been significantly correlated with enhanced cellular proliferation, invasion, and poor prognosis in cancer patients. Furthermore, TRPM2 is pivotal in regulating Ca²⁺ levels, maintaining the mitochondrial function, and inducing cell cycle arrest, all contributing to tumor progression. This review examines the significance of the TRPM2 channel in tumor development and highlights its potential as a therapeutic target for inhibiting cell growth, apoptosis, migration, invasion, angiogenesis, and resistance to chemotherapy drugs. The evidence suggests that the targeted modulation of the TRPM2 channel could be invaluable in diagnosing and treating tumors.

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TRPM2：肿瘤进展的关键参与者和有希望的治疗靶点。

TRPM2是TRPM家族成员之一，是一种位于细胞膜上的非选择性阳离子通道。该通道由adp核糖（ADPR）激活，普遍存在于各种正常组织中，在许多生理和药理过程中起着关键作用，特别是在维持钙稳态方面。大量证据表明，TRPM2的表达升高与多种癌症类型有关。TRPM2表达升高与肿瘤患者细胞增殖、侵袭增强及预后不良有显著相关性。此外，TRPM2在调节Ca2+水平、维持线粒体功能和诱导细胞周期阻滞中起关键作用，所有这些都有助于肿瘤的进展。本文综述了TRPM2通道在肿瘤发展中的意义，并强调了其作为抑制细胞生长、凋亡、迁移、侵袭、血管生成和化疗药物耐药的治疗靶点的潜力。证据表明，TRPM2通道的靶向调节在肿瘤的诊断和治疗中可能是无价的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.