Palladium-Catalyzed Stereoselective Difunctionalization of Skipped 1,4-Enynes With Imines and Organoboronic Acids.

IF 3.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2025-10-15 DOI:10.1002/asia.202500873

Bo Zhu, Xiao-Jun Wang, Qi-Yin Liu, Xin-Ting Qin, Zhi-Chao Chen, Wei Du, Ying-Chun Chen

引用次数: 0

Abstract

Presented herein is a palladium-catalyzed three-component reaction involving skipped 1,4-enynes, imines and organoboronic acids, proceeding in a cascade isomerization, vinylogous addition and Suzuki coupling process. A range of chiral homoallylic amines are constructed in moderate to good yields with excellent regio- and (E,E)-selectivity and fair to high enantioselectivity.

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钯催化的跳过1,4-炔与亚胺和有机硼酸的立体选择性双官能化。

本文介绍了钯催化的三组分反应，包括跳过的1,4-烯，亚胺和有机硼酸，进行级联异构化，葡萄状加成和铃木偶联过程。一系列手性同丙烯基胺以中等到较高的产率合成，具有优异的区域选择性和（E，E）选择性和相当高的对映体选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).