Front Cover: Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle-Based Delivery (Chem. Rec. 10/2025)

IF 7.5 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical record Pub Date : 2025-10-15 DOI:10.1002/tcr.70050

Valentina Arciuolo, Federica D’Aria, Maria Rita Caruso, Martina Maria Calvino, Jussara Amato, Giuseppe Lazzara, Stefana Milioto, Concetta Giancola, Giuseppe Cavallaro, Bruno Pagano

引用次数: 0

Abstract

The cover illustrates G-quadruplex-forming aptamers as therapeutic oligonucleotides for neurodegenerative diseases. Their unique secondary structures confer high target specificity, while clay-based nanocarriers, including halloysite nanotubes and montmorillonite, are depicted as stabilizing and delivery platforms. This combination provides exciting opportunities to enhance nuclease resistance, bioavailability, and targeted transport across biological barriers. More details can be found in the Review by Bruno Pagano and co-workers (DOI: 10.1002/tcr.202500126).

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封面：神经退行性疾病的治疗性寡核苷酸：适配体策略和基于粘土纳米颗粒的递送（化学）。Rec。10/2025)

封面说明了g -四联体形成适体作为神经退行性疾病的治疗寡核苷酸。它们独特的二级结构赋予了高靶向特异性，而粘土基纳米载体，包括高岭土纳米管和蒙脱土，被描述为稳定和递送平台。这种组合为增强核酸酶抗性、生物利用度和跨越生物屏障的靶向运输提供了令人兴奋的机会。更多细节可以在Bruno Pagano及其同事的评论中找到（DOI: 10.1002/tcr.202500126）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.