Guanidine hydrochloride-catalyzed synthesis of hexahydroquinoline-3-carboxamide derivatives in aqueous medium: an efficient and expeditious approach

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2025-10-03 DOI:10.1007/s11164-025-05754-7

Angad B. Barkule, Yatin U. Gadkari, Savita B. Lomte, Shrikant M. Ghodse, Vikas N. Telvekar

引用次数: 0

Abstract

We have developed an eco-friendly method for synthesizing hexahydroquinoline-3-carboxamide derivatives using guanidine hydrochloride as a catalyst in water. This one-pot, multicomponent reaction combines aromatic or heteroaromatic aldehydes, dimedone, acetoacetanilide, and ammonium acetate to produce high yields of the desired compounds. The catalyst also showed remarkable reusability, maintaining its effectiveness over five successive cycles without notable degradation. The approach boasts several advantages, including a sustainable reaction profile, streamlined processing, rapid reaction times, and efficient atom economy, making it an appealing and environmentally responsible approach.

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盐酸胍催化在水介质中合成六氢喹啉-3-羧酸酰胺衍生物：一种高效快捷的方法

研究了以盐酸胍为催化剂在水中合成六氢喹啉-3-羧酸酰胺衍生物的环保方法。这种一锅多组分反应将芳香族或杂芳香族醛、二美酮、乙酰乙酰苯胺和乙酸铵结合在一起，以产生高收率的所需化合物。催化剂还显示出显著的可重复使用性，在连续五个循环中保持其有效性而没有明显的降解。该方法具有几个优点，包括可持续的反应概况、简化的处理、快速的反应时间和高效的原子经济性，使其成为一种吸引人且对环境负责的方法。图形抽象

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.