RadioPharm: the database of radiopharmaceuticals

IF 13.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleic Acids Research Pub Date : 2025-10-16 DOI:10.1093/nar/gkaf1021

Jie Liu, Xingang Liu, Yusha Zhang, Xuedong Li, Yujie Sun, Tingting Li, Lingfang Wei, Minjie Mou, Hao Yang, Pingfan Yuan, Xin Li, Ziyi Zhang, Yuhan Jia, Yan Fu, Yintao Zhang, Yang Zhang, Qingzhong Jia, Feng Zhu

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引用次数: 0

Abstract

Radiopharmaceuticals (RPs) have emerged as a promising group of therapeutic/diagnostic agents with tremendous pharmaceutical advantages and profitable market value. With the rapid advances in this direction, there is an increasing demand for a knowledge base providing RP-relevant data. However, no such database has been available yet. Herein, a database RadioPharm was therefore developed to depict the pharmaceutical data for 3141 RPs and the radioactive characteristics for the nuclide in each RP. Particularly, our RadioPharm is unique in (i) providing the largest number of RPs (including 68 approved, 575 in clinical trials, and 2498 investigative RPs) among the existing databases, (ii) offering the comprehensive radioactive characteristics for the radionuclide in each RP, and (iii) implementing a multidirectional approach for data retrieval (from diverse perspectives of RP, radionuclide, target, and indication). Because of the important role of all those accumulated data in radiopharmaceutical research, RadioPharm is expected to attract broad interest from research community, which is now fully accessible by all users at https://idrblab.org/radiopharm/.

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RadioPharm：放射性药物数据库

放射性药物以其巨大的医药优势和可观的市场价值，成为一种具有发展前景的治疗/诊断试剂。随着这个方向的快速发展，对提供rp相关数据的知识库的需求越来越大。然而，目前还没有这样的数据库。因此，RadioPharm开发了一个数据库来描述3141个RP的药物数据和每个RP中核素的放射性特征。特别是，我们的RadioPharm在以下方面是独一无二的：(i)在现有数据库中提供最多的RP（包括68个已批准的RP， 575个临床试验中的RP和2498个调查性RP），（ii）提供每个RP中放射性核素的综合放射性特征，以及（iii）实施多向数据检索方法（从RP，放射性核素，靶标和适应症的不同角度）。由于所有这些积累的数据在放射性药物研究中的重要作用，RadioPharm预计将吸引研究界的广泛兴趣，现在所有用户都可以在https://idrblab.org/radiopharm/上完全访问。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.