Xiao Mei Han, Bao Yi Zheng, Zhi Cui Liu, Jun Bing Chen, Shu Ting Huang, Lin Xiao, Dong Feng Wang, Zhi Jun Liu
{"title":"Human Cytomegalovirus Infection and Embryonic Malformations: The Role of the <i>Wnt</i> Signaling Pathway and Management Strategies.","authors":"Xiao Mei Han, Bao Yi Zheng, Zhi Cui Liu, Jun Bing Chen, Shu Ting Huang, Lin Xiao, Dong Feng Wang, Zhi Jun Liu","doi":"10.3967/bes2025.103","DOIUrl":null,"url":null,"abstract":"<p><p>Human cytomegalovirus (HCMV) poses a significant risk of neural damage during pregnancy. As the most prevalent intrauterine infectious agent in low- and middle-income countries, HCMV disrupts the development of neural stem cells, leading to fetal malformations and abnormal structural and physiological functions in the fetal brain. This review summarizes the current understanding of how HCMV infection dysregulates the <i>Wnt</i> signaling pathway to induce fetal malformations and discusses current management strategies.</p>","PeriodicalId":93903,"journal":{"name":"Biomedical and environmental sciences : BES","volume":"38 9","pages":"1142-1149"},"PeriodicalIF":4.1000,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical and environmental sciences : BES","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3967/bes2025.103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Human cytomegalovirus (HCMV) poses a significant risk of neural damage during pregnancy. As the most prevalent intrauterine infectious agent in low- and middle-income countries, HCMV disrupts the development of neural stem cells, leading to fetal malformations and abnormal structural and physiological functions in the fetal brain. This review summarizes the current understanding of how HCMV infection dysregulates the Wnt signaling pathway to induce fetal malformations and discusses current management strategies.
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