Prevalence of Borrelia miyamotoi and Neoehrlichia mikurensis in a cohort of tick-exposed individuals and population controls in Denmark 2002–2021

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases Pub Date : 2025-11-01 Epub Date: 2025-10-14 DOI:10.1016/j.ttbdis.2025.102557

Helene Mens , Rosa Gynthersen , Nanna Skaarup Andersen , Mathilde Ørbæk , Fredrikke C. Knudtzen , Sanne Løkkegaard Larsen , Sigurdur Skarphedinsson , Olga A. Stukolova , Dieuwertje Hoornstra , Joppe W. Hovius , Anne-Mette Lebech

{"title":"Prevalence of Borrelia miyamotoi and Neoehrlichia mikurensis in a cohort of tick-exposed individuals and population controls in Denmark 2002–2021","authors":"Helene Mens , Rosa Gynthersen , Nanna Skaarup Andersen , Mathilde Ørbæk , Fredrikke C. Knudtzen , Sanne Løkkegaard Larsen , Sigurdur Skarphedinsson , Olga A. Stukolova , Dieuwertje Hoornstra , Joppe W. Hovius , Anne-Mette Lebech","doi":"10.1016/j.ttbdis.2025.102557","DOIUrl":null,"url":null,"abstract":"<div><div><em>Borrelia miyamotoi</em> and <em>Neoehrlichia mikurensis</em> are recently discovered tick-borne pathogens. The aim of this study was to ascertain the extent of transmission among high-risk groups and healthy controls.</div><div>The study design is retrospective cohort study. Blood from a total of 1180 individuals, collected between 2002–2021: (i) 180 tick-exposed individuals, (ii) 400 immunocompromised individuals and (iii) 600 blood donors was included. Infection was examined by a protein array (<em>B. miyamotoi</em>) and PCR.</div><div><em>Neoehrlichia mikurensis</em> DNA was detected in only one individual with Lyme neuroborreliosis (LNB) with symptoms compatible with both infections. <em>Borrelia miyamotoi</em> seroprevalence (being either IgM or IgG positive) among tick-exposed individuals (8.3 %, 95%CI 5.1–13.3) was significantly higher compared to healthy blood donors (1.5 %, 95 % CI 0.8–2.8) and immunocompromised individuals (3.3 %, 95 %CI 1.9–5.5), <em>p</em> < 0.0001. Altogether, 37 of 1180 individuals (3.1 %, 95 %CI 2.2–4.3) were found to be <em>B. miyamotoi</em> seropositive.</div><div>Neoehrlichiosis and <em>Borrelia miyamotoi</em> disease should be considered in patients with febrile illness and relevant exposure and in non-characteristic presentations of Lyme borreliosis in Denmark.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 6","pages":"Article 102557"},"PeriodicalIF":3.4000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ticks and Tick-borne Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877959X25001219","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/14 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Borrelia miyamotoi and Neoehrlichia mikurensis are recently discovered tick-borne pathogens. The aim of this study was to ascertain the extent of transmission among high-risk groups and healthy controls.

The study design is retrospective cohort study. Blood from a total of 1180 individuals, collected between 2002–2021: (i) 180 tick-exposed individuals, (ii) 400 immunocompromised individuals and (iii) 600 blood donors was included. Infection was examined by a protein array (B. miyamotoi) and PCR.

Neoehrlichia mikurensis DNA was detected in only one individual with Lyme neuroborreliosis (LNB) with symptoms compatible with both infections. Borrelia miyamotoi seroprevalence (being either IgM or IgG positive) among tick-exposed individuals (8.3 %, 95%CI 5.1–13.3) was significantly higher compared to healthy blood donors (1.5 %, 95 % CI 0.8–2.8) and immunocompromised individuals (3.3 %, 95 %CI 1.9–5.5), p < 0.0001. Altogether, 37 of 1180 individuals (3.1 %, 95 %CI 2.2–4.3) were found to be B. miyamotoi seropositive.

Neoehrlichiosis and Borrelia miyamotoi disease should be considered in patients with febrile illness and relevant exposure and in non-characteristic presentations of Lyme borreliosis in Denmark.

查看原文本刊更多论文

2002-2021年丹麦接触蜱虫人群中宫本氏疏螺旋体和米库新立克体的流行情况和人口控制

宫本疏螺旋体和mikurenneehrichia是最近发现的蜱传病原体。本研究的目的是确定高危人群和健康对照组之间的传播程度。研究设计为回顾性队列研究。从2002-2021年期间收集的总共1180人的血液包括：(i) 180名蜱虫暴露者，（ii） 400名免疫功能低下者和（iii） 600名献血者。用宫氏杆菌（B. miyamotoi）和PCR检测感染情况。仅在一例莱姆病神经疏螺旋体（LNB）患者中检测到mikurensis DNA，其症状与两种感染相一致。与健康献血者（1.5%,95%CI 0.8-2.8）和免疫功能不全者（3.3%,95%CI 1.9-5.5）相比，接触蜱虫的个体（8.3%，IgM或IgG阳性）的宫氏疏螺旋体血清阳性率（p < 0.0001）显著高于健康献血者（8.3%,95%CI 5.1-13.3）。1180例患者中37例（3.1%,95% CI 2.2 ~ 4.3）血清阳性。在丹麦，在有发热性疾病和相关暴露的患者以及莱姆病的非特征性表现的患者中，应考虑新立毛体病和宫本氏疏螺旋体病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ticks and Tick-borne Diseases INFECTIOUS DISEASES-MICROBIOLOGY

CiteScore

6.90

自引率

12.50%

发文量

185

审稿时长

6-12 weeks

期刊介绍： Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials. The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.