Comparison of asprosin immunoreactivity in endometrial hyperplasia and grade-1 endometrial adenocarcinoma: A retrospective case-control study.

IF 1.3 Q4 OBSTETRICS & GYNECOLOGY
Ahmet Şenocak, Şeyda Yavuzkır, Remzi Atılgan, Nurdan Yurt, Hilal Balta, Serhat Hançer, Tuncay Kuloğlu, Mustafa Yılmaz, Şehmus Pala, Bünyamin Çim
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引用次数: 0

Abstract

Objective: It has been demonstrated that asprosin, a glucogenic adipokine released by white adipose tissue, contributes to the pathophysiology of cancer and disorders associated with it. The aim of this study was to compare the immunoreactivity of asprosin in grade I endometrial adenocarcinoma and in endometrial hyperplasia (EH) with and without atypia.

Materials and methods: A total of 80 cases previously diagnosed with grade 1 endometrial adenocarcinoma and EH with and without atypia, and for which paraffin blocks were obtained, were included in the study. The resulting paraffin blocks were sectioned again and immunostained for asprosin. A total of 80 cases were divided into 4 groups according to their histopathological diagnoses. Group (G) 1 (n=20): proliferative endometrium, G2 (n=20): EH without atypia, G3 (n=20): EH with atypia, G4 (n=20): Grade 1 endometrial adenocarcinoma. Endometrial samples from 80 patients were sectioned, and asprosin immunoreactivity was evaluated by immunohistochemical staining under a light microscope.

Results: In comparison to the proliferative endometrium group, the grade I endometrial adenocarcinoma group had considerably increased asprosin immunoreactivity. However, between the proliferative endometrium group and the groups with endometrial hyperplasia, without atypia, and endometrial hyperplasia, with atypia, there was no significant difference in asprosin immunoreactivity.

Conclusion: While asprosin immunoreactivity scores are higher in grade I endometrial adenocarcinomas, they are similar to those of the proliferative endometrium in cases of EH with and without atypia, suggesting that energy metabolism contributes to the development of cancer arising from endometrial hyperplasia. Asprosin immunoreactivity can be studied as a marker to predict the progression of EH to cancer.

子宫内膜增生和1级子宫内膜腺癌中阿霉素免疫反应性的比较:一项回顾性病例对照研究。
目的:研究表明,白色脂肪组织释放的糖原性脂肪因子asprosin参与了癌症及其相关疾病的病理生理。本研究的目的是比较asprosin在伴有和不伴有异型性的I级子宫内膜腺癌和子宫内膜增生(EH)中的免疫反应性。材料和方法:本研究共纳入80例既往诊断为1级子宫内膜腺癌和EH,伴或不伴异型,并获得石蜡块的病例。所得到的石蜡块再次切片,并进行asprosin免疫染色。80例患者根据组织病理诊断分为4组。组(G) 1 (n=20):增生性子宫内膜,G2 (n=20):无异型性EH, G3 (n=20):有异型性EH, G4 (n=20): 1级子宫内膜腺癌。80例患者子宫内膜切片,光镜下免疫组化染色评价asprosin免疫反应性。结果:与增殖性子宫内膜组相比,I级子宫内膜腺癌组asprosin免疫反应性明显升高。而增生性子宫内膜组与不异型性子宫内膜增生组、不异型性子宫内膜增生组、不异型性子宫内膜增生组之间,asprosin免疫反应性差异无统计学意义。结论:虽然I级子宫内膜腺癌的asprosin免疫反应性评分较高,但与伴或不伴异型的EH的增殖性子宫内膜相似,提示能量代谢参与了子宫内膜增生引起的癌症的发展。Asprosin免疫反应性可作为预测EH向肿瘤发展的标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.10
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