Antenatal Late Preterm Infants Exposure to Steroids (ALPINES) and Risk of Respiratory Distress and Hypoglycemia: A Retrospective Chart Review.

IF 2.3 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-10-01 DOI:10.1002/ppul.71336

Naveed Ur Rehman Durrani, Maria Bashir Ibrahim Mohammed, Farhan Sachal Cyprian, Muhammad Naseem Khan

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引用次数: 0

Abstract

Introduction: There is a need for a better understanding of the use of antenatal steroids (ANS) in late preterm infants due to their efficacy and safety profile from existing evidence.

Aims: To identify the real-world impact of ANS on short-term outcomes in late preterm infants at a quaternary care setting in Qatar.

Methods: Retrospective chart review of 654 late preterm infants delivered at Sidra Medicine between 1st January 2018 and 29th February 2024. After excluding criteria, infants were categorized based on their exposure to ANS. We utilized regression models to analyze the relationship between ANS exposure and primary and secondary outcomes, including respiratory distress, Noninvasive respiratory support, hypoglycemia, and length of NICU stay, respectively, while adjusting for relevant maternal and infant characteristics.

Results: Our findings reveal no significant protective effect of any ANS dosage against respiratory distress (adjusted odd ratio (aOR) 0.78; 95% CI: 0.46-1.32; p = 0.357). Conversely, ANS exposure was associated with an increased risk of hypoglycemia (aOR 1.22; 95% CI: 0.81-1.84; p = 0.350) and prolonged stay in NICU (incidence rate ratio [IRR] 1.90; 95% CI: 1.74-2.08; p < 0.001).

Conclusion: Our study findings suggest a lack of protection against respiratory distress in late preterm infants with any ANS, highlighting the need for better understanding and adopting an individualized approach.

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产前晚期早产儿暴露于类固醇（ALPINES）和呼吸窘迫和低血糖的风险：回顾性图表回顾。

从现有证据来看，有必要更好地了解晚期早产儿使用产前类固醇（ANS）的有效性和安全性。目的：确定ANS对卡塔尔四级护理环境中晚期早产儿短期结局的实际影响。方法：回顾性分析2018年1月1日至2024年2月29日在锡德拉医学中心分娩的654例晚期早产儿。排除标准后，根据婴儿接触ANS的情况对其进行分类。我们利用回归模型分别分析ANS接触与主要和次要结局（包括呼吸窘迫、无创呼吸支持、低血糖和新生儿重症监护病房住院时间）之间的关系，同时调整相关的母婴特征。结果：我们的研究结果显示，任何剂量的ANS对呼吸窘迫没有显著的保护作用(调整奇数比（aOR） 0.78；95% ci: 0.46-1.32；p = 0.357)。相反，ANS暴露与低血糖风险增加（aOR 1.22; 95% CI: 0.81-1.84; p = 0.350）和NICU住院时间延长（发病率比[IRR] 1.90; 95% CI: 1.74-2.08; p）相关。结论：我们的研究结果表明，任何ANS的晚期早产儿缺乏对呼吸窘迫的保护，强调需要更好地理解和采用个性化的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.