{"title":"Shear Wave Elastography-Based Quantitative Assessment of Carotid Artery Elasticity in Uremic Patients With Different Left Ventricular Configurations.","authors":"Xinyao Wang, Dongmei Huang, Hongyan Cui","doi":"10.1002/jcu.70110","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the potential clinical value of shear wave elastography (SWE) for quantitatively assessing carotid artery elasticity in uremic patients with different left ventricular configurations.</p><p><strong>Methods: </strong>According to different left ventricular configurations, 133 patients diagnosed with uremia were divided into four groups: group B (normal configuration, NG, n = 37), group C (centripetal remodeling, CR, n = 37), group D (centripetal hypertrophy, CH, n = 38), and group E (eccentric hypertrophy, EH, n = 21). Additionally, a control group (group A) consisting of 40 healthy volunteers was selected. None of the subjects exhibited plaque formation in their carotid arteries. Conventional carotid ultrasound was used to assess the intima-media thickness (IMT), peak systolic velocity (PSV), and the systolic and diastolic diameters (Ds and Dd) of the left common carotid artery. Moreover, the wall motion degrees (ΔD) and arterial stiffness coefficient (β) were calculated. The maximum elastic modulus (MEmax), mean elastic modulus (MEmean), and minimum elastic modulus (MEmin) of the carotid artery anterior wall intima-media were obtained using SWE.</p><p><strong>Results: </strong>Compared with group A, the IMT and β values in groups B and C were increased; however, the differences among the three groups were not statistically significant (p > 0.05). In contrast, groups D and E exhibited markedly elevated IMT and β values, which were significantly different from those in groups A, B, and C (p < 0.05). Groups B through E exhibited significantly elevated MEmax, MEmean, and MEmin values in comparison to group A. Statistically significant intergroup differences were identified (p < 0.05), reflecting a stepwise increase in the order of E > D > C > B > A. The linear regression analysis revealed a statistically significant association between different left ventricular configurations and SWE parameters in patients with uremia (p < 0.05).</p><p><strong>Conclusion: </strong>SWE can quantitatively assess carotid artery elasticity in uremic patients with different left ventricular configurations.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Ultrasound","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jcu.70110","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ACOUSTICS","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate the potential clinical value of shear wave elastography (SWE) for quantitatively assessing carotid artery elasticity in uremic patients with different left ventricular configurations.
Methods: According to different left ventricular configurations, 133 patients diagnosed with uremia were divided into four groups: group B (normal configuration, NG, n = 37), group C (centripetal remodeling, CR, n = 37), group D (centripetal hypertrophy, CH, n = 38), and group E (eccentric hypertrophy, EH, n = 21). Additionally, a control group (group A) consisting of 40 healthy volunteers was selected. None of the subjects exhibited plaque formation in their carotid arteries. Conventional carotid ultrasound was used to assess the intima-media thickness (IMT), peak systolic velocity (PSV), and the systolic and diastolic diameters (Ds and Dd) of the left common carotid artery. Moreover, the wall motion degrees (ΔD) and arterial stiffness coefficient (β) were calculated. The maximum elastic modulus (MEmax), mean elastic modulus (MEmean), and minimum elastic modulus (MEmin) of the carotid artery anterior wall intima-media were obtained using SWE.
Results: Compared with group A, the IMT and β values in groups B and C were increased; however, the differences among the three groups were not statistically significant (p > 0.05). In contrast, groups D and E exhibited markedly elevated IMT and β values, which were significantly different from those in groups A, B, and C (p < 0.05). Groups B through E exhibited significantly elevated MEmax, MEmean, and MEmin values in comparison to group A. Statistically significant intergroup differences were identified (p < 0.05), reflecting a stepwise increase in the order of E > D > C > B > A. The linear regression analysis revealed a statistically significant association between different left ventricular configurations and SWE parameters in patients with uremia (p < 0.05).
Conclusion: SWE can quantitatively assess carotid artery elasticity in uremic patients with different left ventricular configurations.
目的：探讨横波弹性成像（SWE）定量评估不同左心室构型尿毒症患者颈动脉弹性的潜在临床价值。方法：将133例确诊为尿毒症的患者根据左心室构型不同分为B组（正常构型NG， n = 37）、C组（向心重构，CR, n = 37）、D组（向心肥厚，CH, n = 38）、E组（偏心肥厚，EH, n = 21）。另外，选取40名健康志愿者作为对照组（a组）。所有受试者的颈动脉均未出现斑块形成。采用常规颈动脉超声检查左颈总动脉内膜-中膜厚度（IMT）、收缩峰值速度（PSV）、收缩和舒张直径（Ds和Dd）。计算了壁面运动度（ΔD）和动脉刚度系数（β）。采用SWE测量颈动脉前壁中内膜的最大弹性模量（MEmax）、平均弹性模量（MEmean）和最小弹性模量（MEmin）。结果：与A组比较，B、C组IMT、β值升高；但三组间差异无统计学意义（p < 0.05）。相比之下，D和E组IMT和β值明显升高，与A、B、C组有显著差异（p D > C > B > A）。线性回归分析显示，尿毒症患者不同左心室构型与SWE参数之间存在显著的相关性(p)。结论：SWE可以定量评估不同左心室构型尿毒症患者颈动脉弹性。
期刊介绍：
The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography.
The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents.
JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.
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