Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters.

IF 5.8 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2025-10-14 DOI:10.1186/s12991-025-00605-6

Yuncheng Zhu, Sheng Li, Ju Gao, Fang Wang, Ni Zhou, Chuangxin Wu, Xiaojia Huang, Ningning Li, Xiaohui Wu, Hongmei Liu, Lu Yang, Xiaoyun Guo, Zuowei Wang, Yiru Fang

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引用次数: 0

Abstract

Background: Theoretical hypotheses suggest differing oxidative stress levels in mood disorders. We evaluated eight oxidative stress-related biochemical markers for further verification in first-onset patients with bipolar disorder (BD) or major depressive disorder (MDD).

Methods: We extracted 224 first-onset patients (BD = 93 and MDD = 131) from the overall sample database of 4647 candidates. And we analyzed eight parameters: direct bilirubin (DBIL), indirect bilirubin (IBIL), uric acid (UA), lactate dehydrogenase (LDH), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), prealbumin, and progesterone.The above parameters enter the hierarchical multiple linear regression model for analysis.

Results: When compared to MDD, the BD group showed decreased prealbumin and elevated UA, LDH, and FT3 in males while decreased prealbumin and DBIL and elevated IDBIL, LDH, FT3 and progesterone in females (p's < 0.05). The model effectively differentiated between BD and MDD, achieving AUCs of 0.894 for men and 0.897 for women.

Conclusion: This result elucidates the validity of these biomarkers for identifying first-episode patients with BD or MDD. The discrimination was satisfactory, with good diagnostic accuracy for both gender subgroups.

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用筛选的生化参数鉴别首发双相情感障碍或重性抑郁症患者。

背景：理论假设表明心境障碍患者的氧化应激水平存在差异。我们评估了八种氧化应激相关的生化标志物，以进一步验证首次发病的双相情感障碍（BD）或重度抑郁症（MDD）患者。方法：从4647例候选人的总样本数据库中提取224例首发患者（BD = 93, MDD = 131）。我们分析了直接胆红素（DBIL）、间接胆红素（IBIL）、尿酸（UA）、乳酸脱氢酶（LDH）、促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、前白蛋白和黄体酮8个参数。以上参数进入层次多元线性回归模型进行分析。结果：与MDD相比，BD组男性的前白蛋白降低，UA、LDH和FT3升高，而女性的前白蛋白和DBIL降低，IDBIL、LDH、FT3和黄体酮升高(p’s结论：这一结果阐明了这些生物标志物在识别首发BD或MDD患者中的有效性。鉴别是令人满意的，对两个性别亚组都有良好的诊断准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.