LncRNA-mRNA integrated networks in the neuroendocrine system of bisphenol a-treated mice induce cellular dysfunctions by disrupting transcriptional homeostasis.

IF 3.2 2区 生物学 Q3 CELL BIOLOGY
Animal Cells and Systems Pub Date : 2025-10-11 eCollection Date: 2025-01-01 DOI:10.1080/19768354.2025.2569881
Seung-Mi Oh, Byeonghwi Lim, Yoon-Been Park, Min-Jae Jang, Seok-Won Lim, Chiwoong Lim, Do-Young Kim, Yejee Park, Young-Jun Seo, Jun-Mo Kim
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引用次数: 0

Abstract

Bisphenol A (BPA) is a widely used xenoestrogen that can disrupt neuroendocrine and immune regulation through multiple hormone receptors. This study investigated BPA-induced long non-coding RNA (lncRNA)-mRNA interactions in the cerebral cortex and hypothalamic-pituitary-thyroid (HPT) axis of adult male mice. Transcriptome sequencing and comprehensive lncRNA annotation identified 14,858 novel lncRNA transcripts. Integrated network analysis using weighted gene co-expression network analysis (WGCNA) revealed four distinct tissue-specific modules: neuronal signaling alterations (Tac1, Htr1b, Npy), RNA splicing modifications (Srsf5), PI3K/Akt-mediated cellular dysfunction (Creb5, Cdkn1a), and immune receptor signaling disruptions (Trbv15, Fcrla). These findings suggest that BPA reprograms transcriptional networks in a tissue-specific manner, potentially disrupting hormone-related neurotransmission, metabolic regulation, and immune signaling via lncRNA-mediated mechanisms. Such systems-level reprogramming of the immune-neuroendocrine network (INEN) provides novel mechanistic insights and biomarker candidates for assessing and mitigating the health impacts of environmental endocrine disruptors.

双酚a处理小鼠神经内分泌系统中的LncRNA-mRNA整合网络通过破坏转录稳态诱导细胞功能障碍。
双酚A (BPA)是一种广泛使用的异种雌激素,可以通过多种激素受体破坏神经内分泌和免疫调节。本研究研究了bpa诱导成年雄性小鼠大脑皮层和下丘脑-垂体-甲状腺(HPT)轴长链非编码RNA (lncRNA)-mRNA的相互作用。转录组测序和综合lncRNA注释鉴定出14,858个新的lncRNA转录物。使用加权基因共表达网络分析(WGCNA)的综合网络分析揭示了四个不同的组织特异性模块:神经元信号改变(Tac1, Htr1b, Npy), RNA剪接修饰(Srsf5), PI3K/ akt介导的细胞功能障碍(Creb5, Cdkn1a)和免疫受体信号中断(Trbv15, Fcrla)。这些发现表明BPA以组织特异性的方式重编程转录网络,可能通过lncrna介导的机制破坏激素相关的神经传递、代谢调节和免疫信号。这种免疫-神经内分泌网络(INEN)的系统级重编程为评估和减轻环境内分泌干扰物对健康的影响提供了新的机制见解和生物标志物候选物。
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来源期刊
Animal Cells and Systems
Animal Cells and Systems 生物-动物学
CiteScore
4.50
自引率
24.10%
发文量
33
审稿时长
6 months
期刊介绍: Animal Cells and Systems is the official journal of the Korean Society for Integrative Biology. This international, peer-reviewed journal publishes original papers that cover diverse aspects of biological sciences including Bioinformatics and Systems Biology, Developmental Biology, Evolution and Systematic Biology, Population Biology, & Animal Behaviour, Molecular and Cellular Biology, Neurobiology and Immunology, and Translational Medicine.
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