Seaweed Derived Polysaccharides as Sustainable Biomaterials for Tissue Engineering Applications.

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-10-15 DOI:10.1021/acsbiomaterials.5c01301

Pradnya Ghalsasi, Gobinath Chithiravelu, Binata Joddar

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引用次数: 0

Abstract

The integration of marine-derived biomaterials has given new directions for fabricating scaffolds that support and influence tissue engineering. Among these, seaweed-derived polysaccharides, such as alginate, agarose, carrageenan, ulvan, laminarin, and fucoidan, present a distinctive combination of structural diversity, functional versatility, and natural abundance. Unlike many synthetic biomaterials, these polysaccharides possess inherent bioactivity, including antioxidant properties and cell signaling cues. These properties can be further tailored through chemical or physical modifications or by combination with other natural or synthetic polymers to suit specific regenerative applications. Fabrication techniques such as 3D printing, electrospinning, microbeads, and hydrogel casting are used to improve the functional outcomes of the scaffolds. Moreover, macroalgae-derived polysaccharides have low-cost production and are environmentally sustainable, making them a preferred choice for clinical applications. This review elaborates on recent advances in the use of seaweed-derived polysaccharide scaffolds for soft and hard tissue engineering. Future efforts should focus on enhancing their clinical translation through deeper biological insights and scalable fabrication.

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海藻多糖作为可持续生物材料在组织工程中的应用。

海洋生物材料的整合为支持和影响组织工程的支架制造提供了新的方向。其中，海藻衍生的多糖，如海藻酸盐、琼脂糖、卡拉胶、藻聚糖、层粘胶蛋白和岩藻聚糖，呈现出结构多样性、功能通用性和天然丰度的独特组合。与许多合成生物材料不同，这些多糖具有固有的生物活性，包括抗氧化特性和细胞信号信号。这些特性可以通过化学或物理改性或与其他天然或合成聚合物结合来进一步定制，以适应特定的再生应用。3D打印、静电纺丝、微珠和水凝胶铸造等制造技术被用于改善支架的功能结果。此外，巨藻来源的多糖生产成本低，环境可持续，使其成为临床应用的首选。本文综述了近年来海藻多糖支架在软硬组织工程中的应用进展。未来的努力应该集中在通过更深入的生物学见解和可扩展的制造来增强它们的临床转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture