Acupuncture Strategies in a Mouse Model of Alzheimer's Disease.

IF 1.2 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Jove-Journal of Visualized Experiments Pub Date : 2025-09-23 DOI:10.3791/68809

Xin Hao, Ning Ding, Yue Zhang, Meng Wu, Yu Ning, Zidong Wang, Zhigang Li

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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Numerous studies have demonstrated that alterations in intestinal flora can influence the central nervous system (CNS) through multiple pathways, ultimately contributing to the onset and progression of AD. Recent research suggests the limitations of pharmacological therapies, emphasizing the need for multi-targeted interventions in AD treatment. Traditional Chinese medicine (TCM) highlights the physiological and pathological relationship between the brain and the intestine. Therefore, therapeutic strategies targeting gastrointestinal regulation to enhance brain function are of great importance for delaying the pathological progression of AD. This protocol introduces a brain-intestine coordination acupuncture method. The experimental results showed that this acupuncture protocol could modulate intestinal flora, suppress intestinal inflammation and neuroinflammation in AD model mice, thereby achieving bidirectional therapeutic effects on brain-intestine regulation. Moreover, a mouse bag fixation device for acupuncture treatment was described in this study, which can reduce stress reaction and improve experimental efficiency.

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针刺策略在老年痴呆症小鼠模型中的应用。

阿尔茨海默病（AD）是一种进行性神经退行性疾病。大量研究表明，肠道菌群的改变可以通过多种途径影响中枢神经系统（CNS），最终导致AD的发生和发展。最近的研究表明了药物治疗的局限性，强调了在阿尔茨海默病治疗中需要多目标干预。中医强调脑和肠之间的生理和病理关系。因此，针对胃肠调节增强脑功能的治疗策略对于延缓AD的病理进展具有重要意义。本方案介绍脑肠配合针刺法。实验结果表明，该针刺方案可调节AD模型小鼠肠道菌群，抑制肠道炎症和神经炎症，从而实现双向脑肠调节的治疗作用。此外，本研究还描述了一种用于针刺治疗的小鼠袋固定装置，可以减少应激反应，提高实验效率。

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来源期刊

Jove-Journal of Visualized Experiments MULTIDISCIPLINARY SCIENCES-

CiteScore

2.10

自引率

0.00%

发文量

992

期刊介绍： JoVE, the Journal of Visualized Experiments, is the world''s first peer reviewed scientific video journal. Established in 2006, JoVE is devoted to publishing scientific research in a visual format to help researchers overcome two of the biggest challenges facing the scientific research community today; poor reproducibility and the time and labor intensive nature of learning new experimental techniques.