PET Imaging of Carotid Atherosclerosis: Methodology, Implications, and Applications in Neurovascular Disease.

IF 8.9 1区医学 Q1 CLINICAL NEUROLOGY

Stroke Pub Date : 2025-10-14 DOI:10.1161/STROKEAHA.125.050399

Shiv Bhakta, John J McCabe, Jason M Tarkin, Mohammed M Chowdhury, Jessica Redgrave, James H F Rudd, Peter J Kelly, Elizabeth A Warburton, Nicholas R Evans

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Abstract

Carotid atherosclerosis is a significant cause of incident and recurrent ischemic stroke, with risk not solely related to the degree of luminal stenosis. Multimodal imaging approaches, including positron emission tomography/computed tomography and positron emission tomography/magnetic resonance imaging, can provide anatomic and molecular evaluation of the atherosclerotic plaque in vivo. Plaque pathophysiology-including the key processes of inflammation and microcalcification-may help characterize stroke risk beyond conventional anatomic assessment alone. This review discusses the use of positron emission tomography in the investigation of carotid atherosclerosis, including methodological considerations, its contributions to our understanding of the underlying disease processes, and how imaging can be used in interventional trials. The clinical implications and potential future applications of positron emission tomography in the assessment and treatment of cerebrovascular disease are also examined.

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颈动脉粥样硬化的PET成像：方法、意义和在神经血管疾病中的应用。

颈动脉粥样硬化是缺血性卒中发生和复发的重要原因，其风险不仅与管腔狭窄程度有关。多模式成像方法，包括正电子发射断层扫描/计算机断层扫描和正电子发射断层扫描/磁共振成像，可以提供体内动脉粥样硬化斑块的解剖和分子评价。斑块病理生理-包括炎症和微钙化的关键过程-可能有助于表征中风风险，而不仅仅是传统的解剖评估。这篇综述讨论了正电子发射断层扫描在颈动脉粥样硬化研究中的应用，包括方法学上的考虑，它对我们理解潜在疾病过程的贡献，以及如何在介入性试验中使用成像。本文还探讨了正电子发射断层扫描在脑血管疾病评估和治疗中的临床意义和潜在的未来应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stroke 医学-临床神经学

CiteScore

13.40

自引率

6.00%

发文量

2021

审稿时长

3 months

期刊介绍： Stroke is a monthly publication that collates reports of clinical and basic investigation of any aspect of the cerebral circulation and its diseases. The publication covers a wide range of disciplines including anesthesiology, critical care medicine, epidemiology, internal medicine, neurology, neuro-ophthalmology, neuropathology, neuropsychology, neurosurgery, nuclear medicine, nursing, radiology, rehabilitation, speech pathology, vascular physiology, and vascular surgery. The audience of Stroke includes neurologists, basic scientists, cardiologists, vascular surgeons, internists, interventionalists, neurosurgeons, nurses, and physiatrists. Stroke is indexed in Biological Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts, CINAHL, Current Contents, Embase, MEDLINE, and Science Citation Index Expanded.