Association Between Thyroid Disease and Scleritis Using a Population-Based Method.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-10-13 DOI:10.1080/09273948.2025.2573737

Kenny Y Wang, Laurel B Tanke, Timothy T Xu, Liang-Yen L Liu, Margaret M Reynolds, David O Hodge, Wendy M Smith

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引用次数: 0

Abstract

Purpose: To investigate the association between scleritis and thyroid eye disease in a U.S. Midwestern county population.

Methods: Retrospective, case-control study of all patients diagnosed with ocular inflammatory disease in Olmsted County, Minnesota from January 1, 2006, to December 31, 2015. Patients were identified using the Rochester Epidemiology Project database, which contains virtually all medical care in the county. Medical records were reviewed to confirm diagnosis of scleritis. A 3:1 age- and sex-matched control group was also identified using the database. Patient records for the cases and control group were also reviewed to confirm diagnosis of thyroid disease.

Results: There were 87 patients with scleritis during the 10-year study period, of which 12 (14%) were diagnosed with thyroid disease. In comparison, there were 261 control patients, of which 30 (11%) had thyroid disease. After adjusting for age, sex, race, smoking status, and history of autoimmune disease, the odds ratio of patients with thyroid disease having scleritis compared to patients without thyroid disease was 1.23 (p = 0.57). However, autoimmune disorders were present in 17 (20%) of scleritis cases versus 16 (6%) patients in the control group (p < 0.001).

Conclusion: There was no statistically significant association between scleritis and thyroid disease in this study. However, there was a significant association between scleritis and other autoimmune diseases. Further research is needed to explore the pathophysiologic mechanisms and systemic associations in thyroid disease and ocular inflammatory diseases.

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基于人群的方法研究甲状腺疾病和巩膜炎之间的关系

目的：调查美国中西部地区人群中巩膜炎和甲状腺眼病之间的关系。方法：对2006年1月1日至2015年12月31日在明尼苏达州奥姆斯特德县诊断为眼部炎症的所有患者进行回顾性、病例对照研究。病人的身份是通过罗彻斯特流行病学项目数据库确定的，该数据库几乎包含了该县所有的医疗服务。检查了医疗记录，以确认巩膜炎的诊断。使用数据库还确定了一个年龄和性别比例为3:1的对照组。同时回顾了病例和对照组的病历，以确认甲状腺疾病的诊断。结果：在10年的研究期间，有87例巩膜炎患者，其中12例（14%）诊断为甲状腺疾病。对照组261例，其中30例（11%）患有甲状腺疾病。在调整了年龄、性别、种族、吸烟状况和自身免疫性疾病史后，患有甲状腺疾病的巩膜炎患者与没有甲状腺疾病的患者的比值比为1.23 （p = 0.57）。然而，与对照组的16例（6%）患者相比，17例（20%）巩膜炎患者存在自身免疫性疾病(p)。结论：在本研究中，巩膜炎与甲状腺疾病之间无统计学意义的关联。然而，在巩膜炎和其他自身免疫性疾病之间有显著的关联。甲状腺疾病和眼部炎性疾病的病理生理机制和系统性关联有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.