Brain linear measurement index in the differential diagnosis between idiopathic normal pressure hydrocephalus and progressive supranuclear palsy.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-10-14 DOI:10.1007/s10072-025-08478-z

Luca Antonina, Donzuso Giulia, Contrafatto Federico, Mostile Giovanni, Cicero Calogero Edoardo, Nicoletti Alessandra, Mario Zappia

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引用次数: 0

Abstract

Background and purpose: Differential diagnosis between idiopathic normal pressure hydrocephalus (iNPH) and progressive supranuclear palsy (PSP) could be challenging, due to the presence of similar clinical and neuroradiological features. Aim of this retrospective study was to differentiate iNPH from PSP by means of brain linear measurement (BLM) index.

Materials and methods: All the enrolled patients underwent a 1.5-T brain-MRI and BLM index was calculated on T1-weighted images. The magnetic resonance hydrocephalic index (MRHI) was also measured. For each index, receiver operating characteristic (ROC) analyses were performed to differentiate between iNPH and PSP obtaining the area under the curve (AUC), sensitivity, specificity, and accuracy values.

Results: Seventy-three patients (35 iNPH and 39 PSP) were consecutively enrolled. BLM and MRHI were significantly higher in iNPH patients than in PSP. In differentiating iNPH from PSP, the BLM index had the highest AUC (0.997) with a sensitivity of 97.1%, a specificity of 100% and an accuracy of 98.6% with an optimal cut-off value of 0.285.

Conclusion: BLM may be useful in the differential diagnosis between iNPH and PSP. At an individual level, the BLM index was the most accurate measure, representing a valid, easy and reliable tool, to achieve an accurate differentiation between these two conditions.

查看原文本刊更多论文

脑线性测量指标在特发性常压脑积水与进行性核上性麻痹鉴别诊断中的应用。

背景和目的：特发性正常压力脑积水（iNPH）和进行性核上性麻痹（PSP）的鉴别诊断可能具有挑战性，因为存在相似的临床和神经影像学特征。本回顾性研究的目的是通过脑线性测量（BLM）指数来区分iNPH和PSP。材料和方法：所有入组患者均行1.5 t脑mri检查，并在t1加权图像上计算BLM指数。同时测定磁共振脑积水指数（MRHI）。对于每个指标，进行受试者工作特征（ROC）分析以区分iNPH和PSP，获得曲线下面积（AUC），灵敏度，特异性和准确性值。结果：73例患者（35例iNPH， 39例PSP）连续入组。iNPH患者的BLM和MRHI明显高于PSP患者。BLM指数鉴别iNPH与PSP的AUC最高（0.997），灵敏度为97.1%，特异性为100%，准确度为98.6%，最佳临界值为0.285。结论：BLM可用于iNPH与PSP的鉴别诊断。在个人层面上，BLM指数是最准确的衡量标准，代表了一种有效、简单和可靠的工具，可以准确区分这两种情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.