Physical exercise and inflammation in Parkinson's disease: a review.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-10-14 DOI:10.1007/s10072-025-08548-2

Chao Han, Hongcui Zhang, Qiang Wang, Pingping Meng, Yuanyuan Hou, Yongxiang Zhang

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引用次数: 0

Abstract

Introduction: Studies have shown that neuroinflammation plays an important role in Parkinson's disease (PD). Current clinical studies provide evidence that physical exercise may enhance pharmacological treatment and alleviate motor impairments in PD patients. However, current understanding of the anti-inflammatory effects of physical exercise in PD is limited. This article reviewed the current state of knowledge concerning the anti-inflammatory properties of physical exercise as an effective therapy for PD.

Methods: A systematic search was conducted for articles published in PubMed, EMBASE and Web of Science from Jan 1973 to Jun 2025.

Results: A total of 41 articles were included in the study. Physical exercise may prevent neurodegeneration in dopaminergic neurons via the inhibition of inflammatory processes. This includes alleviating the inflammatory activity of glia cells, modulating inflammasomes and inflammatory factors through inflammatory pathways and altering the composition of the gut microbiota.

Conclusion: This review presents the current evidence supporting the anti-inflammatory effects of physical exercise as a potential therapy for PD. However, it is not clear how inflammation can further cause the continuous degeneration of dopaminergic neurons, and the specific neuroimmune-modifying mechanism of exercise needs further research.

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帕金森病的体育锻炼与炎症：综述

研究表明，神经炎症在帕金森病（PD）中起着重要作用。目前的临床研究表明，体育锻炼可以增强PD患者的药物治疗，减轻运动障碍。然而，目前对体育锻炼对帕金森病的抗炎作用的了解有限。本文综述了体育锻炼作为帕金森病有效治疗方法的抗炎特性的最新研究进展。方法：系统检索1973年1月~ 2025年6月在PubMed、EMBASE和Web of Science上发表的文章。结果：共纳入41篇文献。体育锻炼可能通过抑制炎症过程来预防多巴胺能神经元的神经变性。这包括减轻神经胶质细胞的炎症活性，通过炎症途径调节炎症小体和炎症因子，以及改变肠道微生物群的组成。结论：本文综述了目前支持体育锻炼作为帕金森病潜在治疗方法的抗炎作用的证据。然而，炎症如何进一步引起多巴胺能神经元的持续变性尚不清楚，运动的特异性神经免疫修饰机制有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.