Global, regional, and national burden of appendicitis among children and adolescents from 1990 to 2021 and projection to 2040: a cross-sectional study.

IF 10.1 2区 医学 Q1 SURGERY
Ying Huang, Dong Peng, Hongbo Huang, Tingting Wei, Chunyan Luo, Jiaying Li, Aijie Zhang, Ze Zhang, Zheng Gong, Zhiqi Hu, Yichen Wang, Guosheng Ren, Yunhai Li, Fan Li
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引用次数: 0

Abstract

Background and importance: Appendicitis is a common surgical emergency in children and adolescents, yet its global epidemiological trends and burden remain understudied. This study aims to analyze the global burden of appendicitis aged 0-19 years from 1990 to 2021.

Methods: We extracted data from the Global Burden of Disease 2021 study to analyze the incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) attributable to appendicitis. Age-standardized rates and trends were stratified by sex, age group, region, and socio-demographic index (SDI).

Results: In 2021, there were 4.53 million new cases of appendicitis and 360,249 DALYs among children and adolescents globally. The highest age-standardized incidence rate (270.38 [95% UI, 180.93 to 386.54]) was observed in High-SDI region, while the highest mortality rate (0.23 [95% UI, 0.14 to 0.35]) occurred in Low-SDI region. From 1990 to 2021, global age-standardized incidence and prevalence rates decreased slightly, while mortality and DALYs declined substantially. However, the age-standardized incidence and prevalence rates began increasing after 2015 and are projected to rise by over 21% by 2040. Frontier analysis highlighted strong performance in Somalia and Niger among low-SDI countries, whereas the United States Virgin Islands, a high-SDI region, exhibited considerable potential for improvement.

Conclusions: The burden of appendicitis among children and adolescents remains significant, with pronounced inequalities across SDI levels. Addressing these inequities requires targeted interventions, such as improving surgical infrastructure in low-SDI regions and optimizing resource utilization in high-SDI regions. These findings provide a foundation for evidence-based policies to ensure equitable care for this vulnerable population.

1990年至2021年全球、区域和国家儿童和青少年阑尾炎负担及2040年预测:一项横断面研究
背景和重要性:阑尾炎是儿童和青少年常见的外科急症,但其全球流行病学趋势和负担仍未得到充分研究。本研究旨在分析1990 - 2021年全球0-19岁阑尾炎负担。方法:我们从全球疾病负担2021研究中提取数据,分析阑尾炎的发病率、患病率、死亡率和残疾调整生命年(DALYs)。年龄标准化率和趋势按性别、年龄组、地区和社会人口指数(SDI)分层。结果:2021年,全球儿童和青少年中有453万新发阑尾炎病例和360249例伤残调整生命年。高sdi区年龄标准化发病率最高(270.38 [95% UI, 180.93 ~ 386.54]),低sdi区死亡率最高(0.23 [95% UI, 0.14 ~ 0.35])。从1990年到2021年,全球年龄标准化发病率和流行率略有下降,而死亡率和伤残调整生命年大幅下降。然而,年龄标准化发病率和流行率在2015年后开始上升,预计到2040年将上升21%以上。前沿分析突出了索马里和尼日尔在低sdi国家中的强劲表现,而美属维尔京群岛是一个高sdi区域,表现出相当大的改善潜力。结论:儿童和青少年的阑尾炎负担仍然很重,在SDI水平上存在明显的不平等。解决这些不平等问题需要有针对性的干预措施,例如改善低sdi地区的手术基础设施,优化高sdi地区的资源利用。这些发现为以证据为基础的政策提供了基础,以确保对这一弱势群体的公平照顾。
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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
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