Global, regional, and national burden of appendicitis among children and adolescents from 1990 to 2021 and projection to 2040: a cross-sectional study.
Ying Huang, Dong Peng, Hongbo Huang, Tingting Wei, Chunyan Luo, Jiaying Li, Aijie Zhang, Ze Zhang, Zheng Gong, Zhiqi Hu, Yichen Wang, Guosheng Ren, Yunhai Li, Fan Li
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引用次数: 0
Abstract
Background and importance: Appendicitis is a common surgical emergency in children and adolescents, yet its global epidemiological trends and burden remain understudied. This study aims to analyze the global burden of appendicitis aged 0-19 years from 1990 to 2021.
Methods: We extracted data from the Global Burden of Disease 2021 study to analyze the incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) attributable to appendicitis. Age-standardized rates and trends were stratified by sex, age group, region, and socio-demographic index (SDI).
Results: In 2021, there were 4.53 million new cases of appendicitis and 360,249 DALYs among children and adolescents globally. The highest age-standardized incidence rate (270.38 [95% UI, 180.93 to 386.54]) was observed in High-SDI region, while the highest mortality rate (0.23 [95% UI, 0.14 to 0.35]) occurred in Low-SDI region. From 1990 to 2021, global age-standardized incidence and prevalence rates decreased slightly, while mortality and DALYs declined substantially. However, the age-standardized incidence and prevalence rates began increasing after 2015 and are projected to rise by over 21% by 2040. Frontier analysis highlighted strong performance in Somalia and Niger among low-SDI countries, whereas the United States Virgin Islands, a high-SDI region, exhibited considerable potential for improvement.
Conclusions: The burden of appendicitis among children and adolescents remains significant, with pronounced inequalities across SDI levels. Addressing these inequities requires targeted interventions, such as improving surgical infrastructure in low-SDI regions and optimizing resource utilization in high-SDI regions. These findings provide a foundation for evidence-based policies to ensure equitable care for this vulnerable population.
期刊介绍:
The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.