Association between blood-derived biological aging and bone mineral density among US adults.

IF 2.4 3区医学 Q2 ORTHOPEDICS

BMC Musculoskeletal Disorders Pub Date : 2025-10-13 DOI:10.1186/s12891-025-09213-7

Longyun Wu, Jing Wang, Xiang Liu, Xueji Wang, Xuefeng Yue

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引用次数: 0

Abstract

Objective: Little is known regarding the association between biological aging and bone mineral density (BMD). This study aimed to assess the effects of biological aging on BMD in US adults.

Methods: This study included 14,499 adults aged 20 or older from NHANES (2005-2010, 2013-2014, and 2017-2018). Biological aging was assessed using two different approaches: biological age and biological age acceleration. Multiple linear regression was used to investigate the relationship between biological aging and BMD. Generalized additive models and smoothed curve fitting were used to examine the dose-response relationship between biological aging and BMD. Multiple logistic regression was used to investigate the relationship between biological aging and the risk of osteoporosis.

Results: After adjusting for potential confounders, our analysis revealed a significant inverse relationship between biological age, biological age acceleration, and BMD at various sites, including the femur neck, total femur, trochanter, and intertrochanter. Furthermore, we observed a significant negative linear correlation between biological age, biological age acceleration, and BMD. Additionally, both biological age and biological age acceleration demonstrated negative associations with the risk of osteoporosis.

Conclusions: Our findings suggest a significant negative association between biological aging and BMD in US adults.

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美国成年人血源性生物老化与骨密度之间的关系。

目的：生物老化与骨密度（BMD）之间的关系尚不清楚。本研究旨在评估生物老化对美国成年人骨密度的影响。方法：本研究纳入了来自NHANES的14499名20岁及以上的成年人（2005-2010、2013-2014和2017-2018）。生物老化的评估采用两种不同的方法：生物年龄和生物年龄加速。采用多元线性回归研究生物老化与骨密度的关系。采用广义加性模型和光滑曲线拟合研究生物老化与骨密度的剂量-反应关系。采用多元logistic回归研究生物老化与骨质疏松风险的关系。结果：在调整了潜在的混杂因素后，我们的分析显示，生物年龄、生物年龄加速和股骨颈、全股骨、粗隆和粗隆间等不同部位的骨密度之间存在显著的负相关关系。此外，我们观察到生物年龄、生物年龄加速和骨密度之间存在显著的负线性相关。此外，生物年龄和生物年龄加速均与骨质疏松症风险呈负相关。结论：我们的研究结果表明，美国成年人的生物衰老与骨密度之间存在显著的负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Musculoskeletal Disorders 医学-风湿病学

CiteScore

3.80

自引率

8.70%

发文量

1017

审稿时长

3-6 weeks

期刊介绍： BMC Musculoskeletal Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of musculoskeletal disorders, as well as related molecular genetics, pathophysiology, and epidemiology. The scope of the Journal covers research into rheumatic diseases where the primary focus relates specifically to a component(s) of the musculoskeletal system.