M. M. Kurshakova, Y. A. Yakusheva, S. G. Georgieva
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引用次数: 0
Abstract
Disruption of the normal expression of histone genes lead to the development of various pathologies. One of the key stages of gene expression is the export of mRNA from the nucleus to the cytoplasm. The TREX-2 protein complex regulates the export of the majority of poly(A)-containing mRNAs. Previously, we demonstrated that TREX-2 is also associated with histone mRNP particles and participates in the nuclear export of histone mRNAs, which lack poly(A)-tails. In this study we investigated the interaction of TREX-2 proteins with the histone mRNA processing machinery. It was shown that TREX-2 interacts with the FLASH protein, a key protein of the specialized histone mRNA processing machinery and a component of the histone locus body (HLB). The TREX-2 complex is recruited through its interaction with FLASH to processed histone mRNAs.
期刊介绍：
Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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