Non-Viral Manufacturing of Cellular Immunotherapy Using Simple Mechanical Transfection Device (Adv. Therap. 10/2025)

Abstract

T-cells forced through micro-sized pores become permeable, letting Chimeric Antigen Receptor (CAR) mRNA enter. The cells then express CAR proteins, gaining potent cancer-killing function. This method offers a path toward efficient, reproducible manufacturing and reduced therapy costs for patients. More details can be found in the Research Article by Cyrus W. Beh and co-workers (DOI: 2500094). Cover image by Ahmad Amirul Abdul Rahim.