The Effect of Iron Deficiency Anemia on the Morphology–Voltage–P Wave Duration (MVP) Risk Score

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Noninvasive Electrocardiology Pub Date : 2025-10-14 DOI:10.1111/anec.70116

Göknur Yildiz, Özge Turgay Yildirim, Şeyhmus Kaya, Fatih Alper Ayyildiz, Can Gökay Yildiz

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引用次数: 0

Abstract

Background

Iron deficiency anemia (IDA) is a common global health issue affecting over two billion people and is associated with cardiovascular complications. Electrocardiographic (ECG) abnormalities may reflect cardiac involvement in IDA. The Morphology-Voltage-P wave Duration (MVP) score, which assesses P-wave duration, voltage, and morphology, is linked to atrial fibrillation (AF) risk. This study aimed to investigate the relationship between IDA and MVP score to evaluate its potential in cardiac risk assessment.

Methods

A prospective study was conducted between January 1 and June 30, 2024, at a tertiary hospital. It included 241 IDA patients and 204 healthy controls. All participants underwent ECG and echocardiography. MVP scores were calculated, and left atrial (LA) diameter and left ventricular ejection fraction (LVEF) were recorded.

Results

MVP scores were significantly higher in the IDA group compared to controls (p < 0.001). P-wave morphology and voltage were notably altered in IDA patients (p < 0.001). LA diameters were larger, and LVEF values were lower in the IDA group (p < 0.001). MVP scores positively correlated with LA size and negatively with LVEF. Additionally, IDA patients had higher heart rates and lower diastolic blood pressure (p < 0.001).

Conclusions

IDA is associated with increased MVP scores, suggesting possible atrial remodeling and higher AF risk. The MVP score may serve as a non-invasive tool for cardiovascular risk stratification in IDA patients. Further research is needed to assess the impact of IDA treatment on ECG parameters and arrhythmia risk.

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缺铁性贫血对形态学-电压- p波持续时间（MVP）风险评分的影响

缺铁性贫血（IDA）是一种常见的全球健康问题，影响着20多亿人，并与心血管并发症有关。心电图（ECG）异常可反映IDA患者心脏受累。形态学-电压- p波持续时间（MVP）评分，评估p波持续时间、电压和形态，与房颤（AF）风险有关。本研究旨在探讨IDA与MVP评分之间的关系，以评估其在心脏风险评估中的潜力。方法前瞻性研究于2024年1月1日至6月30日在某三级医院进行。其中包括241名IDA患者和204名健康对照者。所有参与者都进行了心电图和超声心动图检查。计算MVP评分，记录左房（LA）内径和左室射血分数（LVEF）。结果IDA组的MVP评分显著高于对照组（p < 0.001）。IDA患者的p波形态和电压明显改变（p < 0.001）。IDA组LA直径更大，LVEF值更低（p < 0.001）。MVP得分与LA大小正相关，与LVEF负相关。此外，IDA患者心率较高，舒张压较低（p < 0.001）。结论：IDA与MVP评分升高相关，提示可能存在心房重构和房颤风险增高。MVP评分可以作为IDA患者心血管风险分层的非侵入性工具。需要进一步研究来评估IDA治疗对心电图参数和心律失常风险的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Noninvasive Electrocardiology 医学-心血管系统

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.