Linan Wu, Shujing Xu, Yang Zhou, Dazhou Shi, Mei Wang, Meehyein Kim, Peng Zhan
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引用次数: 0
Abstract
The burgeoning field of proximity-inducing modalities has revolutionized antiviral agent development by harnessing the power of molecular proximity to regulate protein-protein or protein-RNA interactions. This review delves into the innovative strategies and breakthroughs in designing antiviral compounds that leverage induced spatial association, a concept with profound implications for both therapeutic applications and fundamental research. We highlight the role of bifunctional molecules in modulating cellular processes to combat viral infections, underscoring their potential within the proximity induction framework. The review encompasses a comprehensive analysis of current applications and future prospects of proximity-inducing molecules in antiviral research, emphasizing their promise for advancing antiviral therapies and infection control strategies.
期刊介绍：
Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field.
Categories of articles include:
Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry.
Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies.
Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.
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