Biodegradable polylactic acid (PLA) copolymer materials: Structural design, synthesis strategy, the relationship between structure and performance, industrial application

IF 13.2 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2025-10-13 DOI:10.1016/j.cej.2025.169602

Rongrong Ji, Fan Mo, Linwei Liang, Chen Tian, Shixing Dong, Chang Deng, Hao Wu, Ling Zhou, Xipo Zhao

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Abstract

Polylactic acid (PLA) is a sustainable polymer renowned for its excellent biocompatibility and biodegradability, and it has found widespread applications in biomedicine, packaging, and additive manufacturing. However, its inherent brittleness and the challenges associated with controlling its degradation rate significantly limit broader utilization. To address these issues, various PLA-based copolymers—such as block, graft, alternating, and random copolymers—have been developed via copolymerization strategies. In this review, we systematically examine the classification, synthetic methodologies, and structure-property relationships of PLA copolymers within an integrated “structure-performance-application” framework, highlighting their applications in biomedical engineering, 3D printing, and sustainable packaging. By providing a comprehensive analysis of design strategies and performance optimization, this work offers both theoretical insights and practical guidance for advancing multifunctional, high-performance PLA-based materials, and outlines prospects for their future development in biomedicine, green materials, and advanced manufacturing.

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生物可降解聚乳酸（PLA）共聚物材料：结构设计、合成策略、结构与性能的关系、工业应用

聚乳酸（PLA）是一种以其优异的生物相容性和可生物降解性而闻名的可持续聚合物，在生物医药、包装和增材制造中得到了广泛的应用。然而，其固有的脆性和控制降解速率的挑战极大地限制了其广泛利用。为了解决这些问题，人们通过共聚策略开发了各种基于pla的共聚物，如嵌段共聚物、接枝共聚物、交替共聚物和无规共聚物。在这篇综述中，我们系统地研究了聚乳酸共聚物的分类、合成方法和结构-性能关系，并将其应用于生物医学工程、3D打印和可持续包装等领域。通过对设计策略和性能优化的全面分析，本研究为推进多功能、高性能pla基材料提供了理论见解和实践指导，并概述了其在生物医学、绿色材料和先进制造方面的未来发展前景。

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来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.