Alzheimer’s alphabet soup: Find the letters “Z-DNA-ZBP1-RIPK1”

IF 26.3 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-10-14 DOI:10.1016/j.immuni.2025.09.010

Jake A. Gertie, Hachung Chung

引用次数: 0

Abstract

Neuroinflammation contributes to Alzheimer’s disease (AD), but the molecules and pathways that initiate inflammation are unclear. In this issue of Immunity, Song et al. demonstrate that ZBP1-RIPK1 signaling in microglia can drive AD, wherein ZBP1 is activated by left-handed Z-DNA leaking from mitochondria, presenting new molecular targets for AD therapeutics.

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阿尔茨海默氏症字母汤：找到字母“Z-DNA-ZBP1-RIPK1”

神经炎症会导致阿尔茨海默病（AD），但引发炎症的分子和途径尚不清楚。在这一期的《免疫》杂志中，Song等人证明了小胶质细胞中的ZBP1- ripk1信号可以驱动AD，其中ZBP1被线粒体的左旋Z-DNA激活，为AD治疗提供了新的分子靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.