Cutting the Gordian knot: Untangling gasdermin C from pyroptosis

IF 26.3 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-10-14 DOI:10.1016/j.immuni.2025.09.015

Zhaoyu Lin, Hai-Bin Ruan

引用次数: 0

Abstract

Membrane targeting and pore formation of gasdermin C are facilitated by its proteolytic cleavage. In this issue of Immunity, Pandey et al. show how cathepsin S cleaves intestinal epithelial gasdermin C to amplify type 2 immune responses.

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切断戈甸结：从焦亡中解开缠结的气皮素C

气真皮蛋白C的蛋白水解作用促进了其膜靶向和孔的形成。在这一期的《免疫》杂志中，Pandey等人展示了组织蛋白酶S如何切割肠上皮气真皮蛋白C以放大2型免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.