Composition, stabilization and delivery of virus-based vaccines: considerations to break free of the cold chain

IF 21 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2025-12-01 Epub Date: 2025-10-14 DOI:10.1016/j.addr.2025.115715

Amaka J. Epoh , Jailen H. Doyle , Irnela Bajrovic , Maria A. Croyle

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Abstract

Within the last 50 years, the emergence and re-emergence of widespread severe viral infections have caused some of the deadliest global pandemics. Thus, development of novel technologies that effectively stabilize and deliver virus-based vaccines are of high priority to public health. This review serves as a primer for those interested in developing and testing novel formulations and methods for administration of vaccines against viral infection. It starts with a brief history of immunization practices and the role they played in the evolution of vaccines available today. A brief section summarizing virus infection and immunology is provided to assist in design of studies for in vivo testing of novel vaccines. Physical properties of viruses are summarized with known physico-chemical mechanisms of virus degradation outlined. General formulation strategies to prevent degradation are discussed. Traditional and novel dosage forms for vaccine and immunization methods and up and coming technologies are also described.

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基于病毒的疫苗的组成、稳定和递送：打破冷链的考虑

在过去的50 年里，广泛的严重病毒感染的出现和重新出现造成了一些最致命的全球流行病。因此，开发能够有效稳定和提供基于病毒的疫苗的新技术是公共卫生的高度优先事项。这篇综述是为那些有兴趣开发和测试新的配方和方法的管理疫苗，以防止病毒感染的入门。首先简要介绍免疫实践的历史以及它们在当今可用疫苗的演变中所起的作用。简要概述了病毒感染和免疫学，以协助设计新的疫苗体内试验的研究。概述了病毒的物理特性，概述了病毒降解的已知物理化学机制。讨论了防止降解的一般配方策略。还介绍了疫苗和免疫方法的传统剂型和新型剂型以及未来的技术。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.