Evaluation of industrial crop emollients from perilla oil, cocoa butter, and wild almond butter extracts: Physicochemical characterization, stability, bioactivity, and clinical efficacy of product formulations in a double-blind trial

IF 6.2 1区农林科学 Q1 AGRICULTURAL ENGINEERING

Industrial Crops and Products Pub Date : 2025-10-11 DOI:10.1016/j.indcrop.2025.122083

Eakkaluk Wongwad , Weeraya Preedalikit , Tammanoon Rungsang , Jukkarin Srivilai , Nattapol Aunsri , Lapatrada Mungmai

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引用次数: 0

Abstract

Perilla frutescens (L.) Britton, Theobroma cacao L., and Irvingia malayana Oliv. ex A.W. Benn. are promising sources of natural emollient-producing crops. The purpose of this study was to explore the potential of perilla oil, cocoa butter, and wild almond butter extracts as alternative emollient sources for use in cosmetic, cosmeceutical, pharmaceutical, and other health-related products. These emollient extracts were assessed for their physicochemical properties, stability, total phenolic and flavonoid contents, as well as their anti-lipid peroxidation and anti-glycation activities. Skincare formulations incorporating perilla oil (in a body moisturizing cream), cocoa butter (in a facial moisturizing gel-cream), and wild almond butter (in a lip balm) were developed and subjected to stability testing. In addition, these products were tested for skin irritation and evaluated for moisturizing efficacy in comparison to currently marketed emollients in 21 human healthy volunteers. The results revealed that the yields of perilla oil, cocoa butter, and wild almond butter were 8.37 %, 5.67 %, and 27.98 %, respectively. Stability testing indicated that higher temperatures (45 ± 2 °C) increased degradation. All extracts contained phenolic and flavonoid compounds. Cocoa butter and wild almond butter extracts demonstrated moderate anti-lipid peroxidation activity, while perilla oil slightly exhibited anti-glycation activity. The skincare formulations were stable, and no signs of severe skin irritation were observed. In addition, they helped reduce transepidermal water loss and significantly improved skin hydration in both perilla and cocoa creams. These findings establish that the emollient extracts can serve as effective alternative emollient-producing crops for use in cosmetic and other health-related products.

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紫苏油、可可脂和野生杏仁脂提取物对工业作物润肤剂的评价：双盲试验中产品配方的理化特性、稳定性、生物活性和临床疗效

紫苏（L.）布里顿，可可可可L，和欧文·马拉亚娜·奥利夫。前A.W.本。是很有希望的天然润肤作物来源。本研究的目的是探索紫苏油、可可脂和野生杏仁脂提取物作为化妆品、药妆品、制药和其他健康相关产品的替代润肤剂来源的潜力。对这些润肤提取物的理化性质、稳定性、总酚和总黄酮含量、抗脂质过氧化和抗糖基化活性进行了评价。研究人员开发了含有紫苏油（用于身体保湿霜）、可可脂（用于面部保湿凝胶霜）和野生杏仁脂（用于润唇膏）的护肤配方，并进行了稳定性测试。此外，在21名健康志愿者中，对这些产品进行了皮肤刺激测试，并与目前上市的润肤剂进行了保湿功效评估。结果表明，紫苏油、可可脂和野生杏仁脂的得率分别为8.37 %、5.67 %和27.98 %。稳定性测试表明，较高的温度（45 ± 2°C）会增加降解。所有提取物均含有酚类和类黄酮化合物。可可脂和野生杏仁脂提取物具有中等的抗脂质过氧化活性，而紫苏油具有轻微的抗糖基化活性。护肤配方稳定，没有观察到严重皮肤刺激的迹象。此外，它们还有助于减少经皮水分流失，并显著改善紫苏和可可乳中的皮肤水合作用。这些发现表明，润肤剂提取物可以作为有效的替代润肤剂生产作物，用于化妆品和其他与健康相关的产品。

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来源期刊

Industrial Crops and Products 农林科学-农业工程

CiteScore

9.50

自引率

8.50%

发文量

1518

审稿时长

43 days

期刊介绍： Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.