S100B protein as a marker of minimal hepatic encephalopathy.

IF 2.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-09-24 DOI:10.5114/pg.2025.154659

Wojciech Pisarek, Jakub Jarmołowicz, Elżbieta Poniewierka

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引用次数: 0

Abstract

Introduction: Minimal hepatic encephalopathy (MHE) is an overlooked impairment of central nervous system function in patients with acute and chronic liver diseases. Its impact on patients' quality of life, prognosis, and the incidence of overt hepatic encephalopathy has been proven. Due to diagnostic difficulties, searching for a serum biomarker for MHE appears to be extremely important.

Aim: The aim of the study was to demonstrate a potential correlation between the serum levels of SB100P protein in patients with MHE symptoms and the levels of SB100P protein in patients with MHE.

Material and methods: Given the association of hepatic encephalopathy with central nervous system damage, the study used the serum level of S100B protein in patients diagnosed with MHE based on the Psychometric Hepatic Encephalopathy Score (PHES) test.

Results: The study results showed a statistically significant correlation between the serum S100B protein level and the PHES test result. It was also found that the S100B protein level was higher than the norm for the healthy population, as provided by the test manufacturer, in 83% of the patients.

Conclusions: These results are promising, suggesting that further research is needed to verify the significance of S100B protein as a biomarker for MHE.

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S100B蛋白作为轻度肝性脑病的标志物。

简介：轻度肝性脑病（MHE）是急性和慢性肝病患者中被忽视的中枢神经系统功能损害。其对患者生活质量、预后和显性肝性脑病发病率的影响已被证实。由于诊断困难，寻找MHE的血清生物标志物显得极其重要。目的：本研究的目的是证明MHE症状患者血清SB100P蛋白水平与MHE患者血清SB100P蛋白水平之间的潜在相关性。材料与方法：考虑到肝性脑病与中枢神经系统损害的相关性，本研究采用基于肝性脑病心理测量评分（PHES）测试诊断为MHE的患者血清S100B蛋白水平。结果：研究结果显示血清S100B蛋白水平与PHES检测结果有统计学意义。还发现，83%的患者的S100B蛋白水平高于测试制造商提供的健康人群的标准。结论：这些结果是有希望的，表明需要进一步的研究来验证S100B蛋白作为MHE生物标志物的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Przegla̜d Gastroenterologiczny GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.20

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastroenterology Review is a journal published each 2 months, aimed at gastroenterologists and general practitioners. Published under the patronage of Consultant in Gastroenterology and Polish Pancreatic Club.