Association of postpartum weight retentions at 4 weeks with large-for-gestational-age infants in the second pregnancy: the Japan environment and children's study.

IF 2.1 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2025-10-09 eCollection Date: 2025-12-01 DOI:10.1007/s40200-025-01749-8

Satoshi Shinohara, Reiji Kojima, Sanae Otawa, Megumi Kushima, Kunio Miyake, Hideki Yui, Tadao Ooka, Hiroshi Yokomichi, Zentaro Yamagata, Ryoji Shinohara

{"title":"Association of postpartum weight retentions at 4 weeks with large-for-gestational-age infants in the second pregnancy: the Japan environment and children's study.","authors":"Satoshi Shinohara, Reiji Kojima, Sanae Otawa, Megumi Kushima, Kunio Miyake, Hideki Yui, Tadao Ooka, Hiroshi Yokomichi, Zentaro Yamagata, Ryoji Shinohara","doi":"10.1007/s40200-025-01749-8","DOIUrl":null,"url":null,"abstract":"Purpose: We aimed to assess the association between postpartum weight retention (PPWR) in the 4th-week post-delivery and the risk of large-for-gestational-age (LGA) infants in the second pregnancy.Methods: This nationwide prospective birth cohort analysis included 3137 women who delivered their first two live singletons between 2011 and 2014. The PPWR was defined as the body mass index (BMI) after 4 weeks of the first birth minus the pre-pregnancy BMI of the first pregnancy. LGA infants were compared among four PPWR groups: less than - 1 (a BMI loss of > 1 unit), - 1 to < 1 (the reference: stable PPWR group), 1 to < 3 (a BMI gain of 1-3 unit) and ≥ 3 (a BMI gain of > 3 unit). PPWR was assessed not only in all women but also in women with a BMI < 25 and ≥ 25 kg/m2, and adjusted odds ratios (ORs) were calculated for LGA infants by multiple logistic regression.Results: The incidence of LGA infants was 8.8% (277 out of 3137). After adjusting for potential confounding factors, no association was observed between the risk of an LGA infant in the second pregnancy and the PPWR in all eligible women. Similarly, no association was observed between LGA risk in the second pregnancy and thePPWR in the pre-pregnancy BMI < 25 kg/m2 (normal) and ≥ 25 kg/m2 (overweight/obese) groups.Conclusion: PPWR measured in the 4th-week post-delivery was not associated with an increased risk of LGA infants in the second pregnancy.Supplementary information: The online version contains supplementary material available at 10.1007/s40200-025-01749-8.","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"215"},"PeriodicalIF":2.1000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511494/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes and Metabolic Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40200-025-01749-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: We aimed to assess the association between postpartum weight retention (PPWR) in the 4th-week post-delivery and the risk of large-for-gestational-age (LGA) infants in the second pregnancy.

Methods: This nationwide prospective birth cohort analysis included 3137 women who delivered their first two live singletons between 2011 and 2014. The PPWR was defined as the body mass index (BMI) after 4 weeks of the first birth minus the pre-pregnancy BMI of the first pregnancy. LGA infants were compared among four PPWR groups: less than - 1 (a BMI loss of > 1 unit), - 1 to < 1 (the reference: stable PPWR group), 1 to < 3 (a BMI gain of 1-3 unit) and ≥ 3 (a BMI gain of > 3 unit). PPWR was assessed not only in all women but also in women with a BMI < 25 and ≥ 25 kg/m², and adjusted odds ratios (ORs) were calculated for LGA infants by multiple logistic regression.

Results: The incidence of LGA infants was 8.8% (277 out of 3137). After adjusting for potential confounding factors, no association was observed between the risk of an LGA infant in the second pregnancy and the PPWR in all eligible women. Similarly, no association was observed between LGA risk in the second pregnancy and thePPWR in the pre-pregnancy BMI < 25 kg/m² (normal) and ≥ 25 kg/m² (overweight/obese) groups.

Conclusion: PPWR measured in the 4th-week post-delivery was not associated with an increased risk of LGA infants in the second pregnancy.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-025-01749-8.

查看原文本刊更多论文

产后4周体重保留与二胎大胎龄儿的关系：日本环境与儿童研究

目的：我们旨在评估产后第4周的产后体重保留（PPWR）与二胎大胎龄儿（LGA）风险的关系。方法：这项全国范围的前瞻性出生队列分析包括3137名在2011年至2014年期间分娩了头两个活单胎的妇女。PPWR被定义为第一次分娩后4周的身体质量指数（BMI）减去第一次怀孕前的身体质量指数。LGA婴儿在四个PPWR组中进行比较：小于- 1 （BMI损失bb0.1单位），- 1至3单位)。我们不仅评估了所有女性的PPWR，还评估了BMI为2的女性的PPWR，并通过多元逻辑回归计算了LGA婴儿的调整优势比（ORs）。结果：LGA患儿发生率为8.8%（3137例中有277例）。在对潜在的混杂因素进行调整后，在所有符合条件的妇女中，未观察到第二次妊娠LGA婴儿的风险与PPWR之间的关联。同样，在孕前BMI 2（正常）和≥25 kg/m2（超重/肥胖）组中，未观察到第二次妊娠LGA风险与ppwr之间的关联。结论：产后第4周测量的PPWR与第二次妊娠LGA婴儿的风险增加无关。补充资料：在线版本提供补充资料，网址为10.1007/s40200-025-01749-8。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.