Tingting Wu, Shuman Wang, Yajing Liu, Xiaoming Bai, Chen Shi
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引用次数: 0
Abstract
Cancer therapeutic resistance remains a major obstacle in clinical oncology, driven by multifaceted mechanisms including multidrug resistance, radioresistance, and immune evasion. Recent advances highlight cuproptosis, a novel copper-dependent programmed cell death modality, as a promising strategy to overcome these challenges. Cuproptosis is triggered by mitochondrial copper overload, leading to lipoylated protein aggregation, tricarboxylic acid cycle disruption, and proteotoxic stress. The regulatory mechanism of copper ions and cuproptosis on cancer offers a unique vulnerability for targeting therapy-resistant malignancies. This review summarized the mechanisms of copper ions, the discovery of cuproptosis, the commonly used copper ionophores and the potential of cuproptosis in overcoming therapeutic resistance, as well as the remaining challenges and future directions concerning cuproptosis. It will provide a novel therapeutic paradigm to overcome cancer therapeutic resistance.
期刊介绍：
The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
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