Validation of Age-adjusted Shock indices for Predicting In-hospital outcomes in percutaneously REvascularized ST-elevation myocardial infarction - ASPIRE-STEMI study.

IF 1.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Indian heart journal Pub Date : 2025-10-10 DOI:10.1016/j.ihj.2025.10.004

Bryan Jacob Koithara, Ravi Kalra, Shashikala Sangle, Supriya Barsode, Shrikant Deshmukh

引用次数: 0

Abstract

The ASPIRE-STEMI study prospectively evaluated 236 patients with ST-elevation myocardial infarction undergoing percutaneous revascularization to validate Age-Shock Index (Age-SI) and Age-Modified Shock Index (Age-MSI) as alternatives to the GRACE score for predicting in-hospital major adverse cardiovascular events (MACE) and all-cause mortality. For MACE (n = 60), optimal cut-offs yielded sensitivities/specificities of 76.7 %/67 % (Age-SI ≥ 36.95), 85 %/56.2 % (Age-MSI ≥45.64), and 60 %/81.9 % (GRACE ≥127.5). For all-cause mortality (n = 17), optimal cut-offs yielded sensitivity/specificity of 82.4 %/83 % (Age-SI ≥46.83), 77 %/89 % (Age-MSI ≥67.35), and 94 %/76.7 % (GRACE ≥127.5). While each index independently predicted in-hospital outcomes, Age-SI and Age-MSI offer simple, bedside risk stratification in Indian STEMI patients post-PCI.

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年龄调整休克指标预测经皮st段抬高型心肌梗死住院预后的验证——ASPIRE-STEMI研究

ASPIRE-STEMI研究前瞻性评估了236例经皮血管重洗术的st段抬高型心肌梗死患者，以验证年龄-休克指数（Age-SI）和年龄修正休克指数（Age-MSI）作为GRACE评分预测住院主要不良心血管事件（MACE）和全因死亡率的替代方法。对于MACE (n=60)，最佳截止值产生的敏感性/特异性分别为76.7%/67% （Age-SI≥36.95）、85%/56.2% （Age-MSI≥45.64）和60%/81.9% （GRACE≥127.5）。对于全因死亡率（n=17），最佳临界值的敏感性/特异性分别为82.4%/83% （Age-SI≥46.83）、77%/89% （Age-MSI≥67.35）和94%/76.7% （GRACE≥127.5）。虽然每个指标都独立预测了住院结果，但Age-SI和Age-MSI为pci后印度STEMI患者提供了简单的床边风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

52 days

期刊介绍： Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.