Interactive effects between lead-cadmium co-exposure and VEGFA gene polymorphisms on renal dysfunction: a gene-environment interaction study.

IF 3.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Frontiers in Public Health Pub Date : 2025-09-25 eCollection Date: 2025-01-01 DOI:10.3389/fpubh.2025.1627634

Yaotang Deng, Yunman Wen, Weixia Duan, Zhiqiang Zhao, Guoliang Li, Jiazhen Zhou, Le Yang, Jieyi Yang, Yapei Sun, Manyi Qiu, Lili Liu

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引用次数: 0

Abstract

Background: Lead (Pb) and cadmium (Cd) are common persistent environmental pollutants, may cause renal dysfunction following long-term exposure. This study investigated whether vascular endothelial growth factor a (VEGFA) gene polymorphisms modify the association between Pb and Cd exposure with renal dysfunction risk, given the key role of gene-environment interactions in kidney pathogenesis.

Methods: A cross-sectional study of 408 workers was undertaken from a Pb-Cd smelter in Guangdong Province, China in 2023. Metals in blood and urine were measured using Inductively coupled plasma-Mass Spectrometry (ICP-MS). Additive, dominant and recessive genetic models were employed to analyze differences in genotype distribution of rs3025010, rs10434 and rs833061 between normal and renal dysfunction groups. Interaction analyses were conducted to examine the combined effects of blood lead (BPb) and urinary cadmium (UCd) exposure with these polymorphisms under different genetic models on renal dysfunction risk.

Results: For rs833061 locus, BPb showed statistically significant differences in both the additive and recessive models (p < 0.05), while renal function exhibited differences in the additive and dominant models (p < 0.05). For rs3025010, BPb showed significant differences in the recessive model (p = 0.05), and renal function demonstrated differences in both additive and dominant models (p < 0.05). Multivariate regression analysis identified BPb and UCd as risk factors for renal dysfunction, with odds ratios ranging from 1.40 to 3.46 (p < 0.05). Interaction analyses revealed interactions between rs3025010 and Pb [BPb × rs3025010: OR (95%CI) = 0.69(0.49, 0.88)] in dominant model. The rs10434 locus interactions with Pb and Cd in both the additive [OR (95%CI) = 0.60 (0.31, 0.91)] and recessive models [OR (95%CI) = 0.51 (0.27, 0.85)].

Conclusion: This study identified significant gene-environment interactions between VEGFA polymorphisms (rs3025010 and rs10434) and Pb-Cd co-exposure in renal dysfunction. These findings suggest that screening for these polymorphisms could identify high-risk populations for targeted prevention and control strategies.

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铅镉共暴露与VEGFA基因多态性对肾功能障碍的相互作用：一项基因-环境相互作用研究。

背景：铅（Pb）和镉（Cd）是常见的持久性环境污染物，长期接触可引起肾功能障碍。鉴于基因-环境相互作用在肾脏发病机制中的关键作用，本研究探讨了血管内皮生长因子a （VEGFA）基因多态性是否改变了铅和镉暴露与肾功能障碍风险之间的关系。方法：对2023年中国广东省某铅镉冶炼厂408名工人进行了横断面研究。采用电感耦合等离子体质谱法（ICP-MS）测定血液和尿液中的金属含量。采用加性遗传、显性遗传和隐性遗传模型分析正常组和肾功能不全组rs3025010、rs10434和rs833061基因型分布的差异。通过相互作用分析，探讨不同遗传模式下血铅（BPb）和尿镉（UCd）暴露及其多态性对肾功能障碍风险的综合影响。结果：对于rs833061位点，BPb在加性模型和隐性模型中均有统计学差异（p p p = 0.05），肾功能在加性模型和显性模型中均有统计学差异（p p ）。结论：本研究发现VEGFA多态性（rs3025010和rs10434）与铅镉共暴露在肾功能障碍中存在显著的基因-环境相互作用。这些发现表明，筛选这些多态性可以确定高危人群，从而制定有针对性的预防和控制策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.